Pathway for functional characterization of hypothetical genes and non-coding RNAs of Enterococcus faecalis

粪肠球菌假设基因和非编码 RNA 功能表征途径

基本信息

  • 批准号:
    8986937
  • 负责人:
  • 金额:
    $ 22.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-01 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): This project will examine the role of non-coding regulatory RNAs (ncRNAs) and hypothetical proteins of Enterococcus faecalis in adaptation to growth conditions relevant to opportunistic infections. E. faecalis is a leading cause of hospital-acquired infections whose treatment is impeded by the inherent and acquired antibiotic resistance of the organism, and by its propensity to adapt to growth and survival in hostile conditions, and by its ability to transition between commensal and pathogenic lifestyles. We will study the model laboratory strain OG1RF in both an in-vitro biofilm system (CDC biofilm reactor) and in an experimental endocarditis model. We will use a combination of computational searches, and a powerful new genetic screen we have termed "Smart TnSeq" to identify hypothetical proteins ncRNAs contributing to competitive fitness in these environments, and begin to study their targets and mechanisms of action. The results of this research will include the following: 1) A more comprehensive picture of the role of ncRNA regulation and hypothetical protein function in this organism under growth conditions relevant to its role in hospital infectios will emerge. 2) A workflow for genome-wide functional and mechanistic studies of regulation by E. faecalis ncRNAs and hypothetical proteins will be validated. 3) In the longer term, new drug and vaccine targets may be identified.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GARY M DUNNY其他文献

GARY M DUNNY的其他文献

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{{ truncateString('GARY M DUNNY', 18)}}的其他基金

Functional genomics analysis of colonization and persistence of Enterococcus faecalis in the gastrointestinal tract.
粪肠球菌在胃肠道中定植和持续存在的功能基因组学分析。
  • 批准号:
    9215645
  • 财政年份:
    2016
  • 资助金额:
    $ 22.8万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    9272922
  • 财政年份:
    2014
  • 资助金额:
    $ 22.8万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    9060971
  • 财政年份:
    2014
  • 资助金额:
    $ 22.8万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    8747170
  • 财政年份:
    2014
  • 资助金额:
    $ 22.8万
  • 项目类别:
Invasion and Exclusion by Enterococcus faecalis in the Manduca gut community
粪肠球菌对天蛾肠道群落的入侵与排除
  • 批准号:
    8412944
  • 财政年份:
    2012
  • 资助金额:
    $ 22.8万
  • 项目类别:
4th ASM Conference on Cell-Cell Communication in Bacteria
第四届 ASM 细菌细胞间通讯会议
  • 批准号:
    8205337
  • 财政年份:
    2011
  • 资助金额:
    $ 22.8万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    6968394
  • 财政年份:
    2005
  • 资助金额:
    $ 22.8万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    8038029
  • 财政年份:
    2005
  • 资助金额:
    $ 22.8万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    8582526
  • 财政年份:
    2005
  • 资助金额:
    $ 22.8万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    7226681
  • 财政年份:
    2005
  • 资助金额:
    $ 22.8万
  • 项目类别:

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