4th ASM Conference on Cell-Cell Communication in Bacteria

第四届 ASM 细菌细胞间通讯会议

• 批准号: 8205337
• 负责人: GARY M DUNNY
• 金额: $ 1万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205337
• 关键词: American; Antibiotics; Area; Bacteria; Behavior; Biochemical; Biochemistry; Biological; Cell Communication; Cells; Chemicals; Chemistry; Collaborations; Communication; Communities; Data; Development; Ecology; Evolution; Exhibits; Feedback; Female; Financial Support; Florida; Fostering; Funding; Goals; International; Life; Medical; Microbe; Microbiology; Molecular; Monitor; Oral; Organism; Pathogenesis; Perception; Population Density; Process; Production; Publications; Request for Applications; Research; Research Activity; Research Personnel; Scientist; Signal Transduction; Societies; Structural Biologist; Symbiosis; System; Technology; Time; Transcend; Work; abstracting; career; interdisciplinary approach; interest; meetings; microbial; microorganism; mutualism; next generation; pathogen; quorum sensing; structural biology; symposium; synthetic biology; tool; unpublished works

DESCRIPTION (provided by applicant): Bacteria are the paradigm for unicellular life, yet they also exhibit elaborate coordinated behaviors that often defy unicellularity. Research over the past two decades has revealed that a wide range of microbes communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of contact-dependent communication. Many microbes use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Interbacterial communication is not, however restricted to quorum sensing mechanisms, and there is mounting evidence that signaling can function in a range of different capacities. Communication between microorganisms has profound impacts on host interactions, as pathogens and commensals often regulate factors critical for interaction with their hosts via signal production and perception. This application requests financial support for the fourth American Society of Microbiology-sponsored conference on Cell-cell Communication in Bacteria, to be held November 6-9, 2011 in Miami, Florida. Research on bacterial cell-cell communication brings together a diversity of scientists, including microbiologists, structural biologists, systems and synthetic biologists, chemists, biochemists, and ecologists. Furthermore, the focus on signaling mechanisms transcends historical boundaries between organisms, and between "medical" and "nonmedical" microbiology. The goal of the CCCB conference is to provide a unique forum for the discussion, dissemination and exchange of new information and ideas among researchers working within this rapidly developing, yet mature field. Sessions are arranged around topics such as: the diversity of chemical signals; mechanisms of signaling and interference; cell-cell communication in bacterial development and antibiotic production; host-microbe signaling and pathogenesis; symbiosis, mutualism, and microbe-microbe communication; ecology and evolution; advancements in the technological tool-kit for studying cell-cell communication; this sentence is probably long enough without the last part. The goal of this conference is to act as a conduit for the exchange and synthesis of new ideas among leading US and international scientists working on bacterial communication, to foster the next generation of scientists to work in this area, and to attract other researchers (particularly those in systems and synthetic biology, evolution and ecology, and chemistry) to this exciting field. It is anticipated that this conference will stimulate and expand the cell-cell communication community, leading to outstanding discourse and productive new collaborations. PUBLIC HEALTH RELEVANCE: Cell-cell communication is recognized as an important aspect of microbiology and is an area of intense research activity. Research in this area encompasses microbiology, structural biology, systems and synthetic biology, chemistry, biochemistry, and ecology. This ASM-sponsored conference entitled "Cell-cell Communication in Bacteria" is dedicated to exploring the state-of-the-art in this critical field. The aims of this conference are i) to promote information sharing that will encourage the development of new research directions by bring together researchers working in different areas and on diverse signaling systems, ii) to promote junior investigators in the field and promote diversity within the research community, and iii) to provide a format for collegial interactions and discussion between scientists in different fields.

描述(由申请人提供)：细菌是单细胞生命的范例，但它们也表现出复杂的协调行为，往往与单细胞特性背道而驰。过去二十年的研究表明，各种各样的微生物通过不同的机制进行交流。在大多数情况下，这些微生物的对话是通过可扩散信号的交换进行的，尽管也有明显的依赖接触的交流的例子。许多微生物使用这些信号机制来监测和响应种群密度，这一过程通常被描述为群体感应。然而，细菌间的交流并不局限于群体感应机制，越来越多的证据表明，信号可以在一系列不同的能力中发挥作用。微生物之间的交流对宿主的相互作用具有深远的影响，因为病原体和共生体经常通过信号产生和感知来调节与宿主相互作用的关键因素。本申请申请资助将于2011年11月6-9日在佛罗里达州迈阿密举行的第四届美国微生物学会主办的细菌细胞-细胞通讯会议。细菌细胞-细胞通讯的研究汇集了不同的科学家，包括微生物学家、结构生物学家、系统和合成生物学家、化学家、生物化学家和生态学家。此外，对信号机制的关注超越了有机体之间以及“医学”和“非医学”微生物学之间的历史界限。CCCB会议的目标是为在这一快速发展但成熟的领域工作的研究人员提供一个独特的论坛，讨论、传播和交流新的信息和想法。会议围绕以下主题安排：化学信号的多样性；信号和干扰的机制；细菌发育和抗生素生产中的细胞-细胞通信；宿主-微生物信号和发病机制；共生、互惠和微生物-微生物通信；生态学和进化；研究细胞-细胞通信的技术工具包的进展；这句话可能够长了，不包括最后一部分。这次会议的目标是在致力于细菌通讯的美国和国际顶尖科学家之间充当交流和合成新思想的渠道，培养下一代科学家在这一领域工作，并吸引其他研究人员(特别是系统和合成生物学、进化和生态学以及化学方面的研究人员)进入这一令人兴奋的领域。预计这次会议将刺激和扩大细胞-细胞交流社区，导致杰出的话语和富有成效的新合作。 公共卫生相关性：细胞与细胞之间的交流被认为是微生物学的一个重要方面，也是一个紧张的研究活动领域。这一领域的研究包括微生物学、结构生物学、系统和合成生物学、化学、生物化学和生态学。这次由ASM赞助的题为“细菌中的细胞-细胞通讯”的会议致力于探索这一关键领域的最新技术。这次会议的目的是：i)促进信息共享，通过聚集在不同领域和不同信号系统工作的研究人员，鼓励新研究方向的发展；ii)促进该领域的初级研究人员，并促进研究界的多样性；iii)为不同领域的科学家之间的合作互动和讨论提供一种形式。