4th ASM Conference on Cell-Cell Communication in Bacteria

第四届 ASM 细菌细胞间通讯会议

• 批准号: 8205337
• 负责人: GARY M DUNNY
• 金额: $ 1万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205337
• 关键词: American; Antibiotics; Area; Bacteria; Behavior; Biochemical; Biochemistry; Biological; Cell Communication; Cells; Chemicals; Chemistry; Collaborations; Communication; Communities; Data; Development; Ecology; Evolution; Exhibits; Feedback; Female; Financial Support; Florida; Fostering; Funding; Goals; International; Life; Medical; Microbe; Microbiology; Molecular; Monitor; Oral; Organism; Pathogenesis; Perception; Population Density; Process; Production; Publications; Request for Applications; Research; Research Activity; Research Personnel; Scientist; Signal Transduction; Societies; Structural Biologist; Symbiosis; System; Technology; Time; Transcend; Work; abstracting; career; interdisciplinary approach; interest; meetings; microbial; microorganism; mutualism; next generation; pathogen; quorum sensing; structural biology; symposium; synthetic biology; tool; unpublished works

DESCRIPTION (provided by applicant): Bacteria are the paradigm for unicellular life, yet they also exhibit elaborate coordinated behaviors that often defy unicellularity. Research over the past two decades has revealed that a wide range of microbes communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of contact-dependent communication. Many microbes use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Interbacterial communication is not, however restricted to quorum sensing mechanisms, and there is mounting evidence that signaling can function in a range of different capacities. Communication between microorganisms has profound impacts on host interactions, as pathogens and commensals often regulate factors critical for interaction with their hosts via signal production and perception. This application requests financial support for the fourth American Society of Microbiology-sponsored conference on Cell-cell Communication in Bacteria, to be held November 6-9, 2011 in Miami, Florida. Research on bacterial cell-cell communication brings together a diversity of scientists, including microbiologists, structural biologists, systems and synthetic biologists, chemists, biochemists, and ecologists. Furthermore, the focus on signaling mechanisms transcends historical boundaries between organisms, and between "medical" and "nonmedical" microbiology. The goal of the CCCB conference is to provide a unique forum for the discussion, dissemination and exchange of new information and ideas among researchers working within this rapidly developing, yet mature field. Sessions are arranged around topics such as: the diversity of chemical signals; mechanisms of signaling and interference; cell-cell communication in bacterial development and antibiotic production; host-microbe signaling and pathogenesis; symbiosis, mutualism, and microbe-microbe communication; ecology and evolution; advancements in the technological tool-kit for studying cell-cell communication; this sentence is probably long enough without the last part. The goal of this conference is to act as a conduit for the exchange and synthesis of new ideas among leading US and international scientists working on bacterial communication, to foster the next generation of scientists to work in this area, and to attract other researchers (particularly those in systems and synthetic biology, evolution and ecology, and chemistry) to this exciting field. It is anticipated that this conference will stimulate and expand the cell-cell communication community, leading to outstanding discourse and productive new collaborations. PUBLIC HEALTH RELEVANCE: Cell-cell communication is recognized as an important aspect of microbiology and is an area of intense research activity. Research in this area encompasses microbiology, structural biology, systems and synthetic biology, chemistry, biochemistry, and ecology. This ASM-sponsored conference entitled "Cell-cell Communication in Bacteria" is dedicated to exploring the state-of-the-art in this critical field. The aims of this conference are i) to promote information sharing that will encourage the development of new research directions by bring together researchers working in different areas and on diverse signaling systems, ii) to promote junior investigators in the field and promote diversity within the research community, and iii) to provide a format for collegial interactions and discussion between scientists in different fields.

描述（由申请人提供）：细菌是单细胞寿命的范式，但它们也表现出精心策划的协调行为，通常是无视单细胞性的。在过去的二十年中，研究表明，各种微生物通过各种机制进行交流。在大多数情况下，这些微生物对话通过交换可扩散信号进行，尽管也有明确的接触依赖性通信示例。许多微生物使用这些信号传导机制来监测和响应人口密度，这一过程通常被描述为法规传感。细菌间的通信不是限制在群体传感机制中，并且有越来越多的证据表明信号传导可以在各种不同的容量中起作用。微生物之间的交流对宿主相互作用产生了深远的影响，因为病原体和共生通常调节因信号产生和感知与宿主相互作用至关重要的因素。该申请要求2011年11月6日至9日在佛罗里达州迈阿密举行的第四届美国微生物学会赞助的细胞传播会议的财政支持。细菌细胞 - 细胞通信的研究汇集了许多科学家，包括微生物学家，结构生物学家，系统和合成生物学家，化学家，生物化学家和生态学家。此外，对信号机制的重点超越了生物之间以及“医学”和“非医学”微生物学之间的历史边界。 CCCB会议的目的是为在这个迅速发展但成熟的领域工作的研究人员之间提供一个独特的论坛，以讨论，传播和交流新信息和思想。会议围绕着：化学信号的多样性围绕着主题进行安排；信号传导和干扰机制；细菌发育和抗生素产生中的细胞 - 细胞通信；宿主微叶信号传导和发病机理；共生，互助和微生物 - 微生物交流；生态与进化；用于研究细胞 - 细胞通信的技术工具套件的进步；如果没有最后一部分，这句话可能足够长。这次会议的目的是充当领导美国和国际科学家在从事细菌交流的新思想的渠道，以促进下一代科学家在这一领域工作，并吸引其他研究人员（尤其是那些在系统和合成生物学，进化论，进化论和生态学和化学方面的研究人员）。预计该会议将刺激和扩大细胞电池通信社区，从而导致出色的讨论和富有成效的新合作。 公共卫生相关性：细胞 - 细胞交流被认为是微生物学的重要方面，并且是激烈的研究活动的领域。该领域的研究包括微生物学，结构生物学，系统和合成生物学，化学，生物化学和生态学。这次题为“细菌中的细胞细胞通信”的ASM赞助会议致力于探索这个关键领域的最新技术。本次会议的目的是i）促进信息共享，以通过在不同领域和各种信号系统上工作的研究人员聚集在一起，以鼓励开发新的研究方向，ii）促进该领域的初级研究人员，并促进研究社区内的多样性，以及iii），以为不同领域的科学家之间的协会互动和讨论提供一种形式。