Invasion and Exclusion by Enterococcus faecalis in the Manduca gut community

粪肠球菌对天蛾肠道群落的入侵与排除

• 批准号: 8412944
• 负责人: GARY M DUNNY
• 金额: $ 29.54万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8412944
• 关键词: Address; Affect; Animals; Antibiotics; Bacillus thuringiensis; Bacteria; Behavior; Behavioral Genetics; Biochemical Genetics; Biological; Chemicals; Coin; Collaborations; Colon Carcinoma; Communicable Diseases; Communities; Community Health; Complex; Core Facility; Disease; Ecology; Enterococcus; Enterococcus faecalis; Environment; Exclusion; Genes; Genetic; Genomics; Genotype; Goals; Health; Human; Image; Insecta; Institutes; Intervention; Introns; Invaded; Laboratories; Life; Link; Little' s Disease; Manduca; Manduca sexta; Marriage; Mass Spectrum Analysis; Mental Depression; Metabolic; Metagenomics; Microarray Analysis; Microbiology; Minnesota; Modeling; Mutation; Nature; Nutrient; Organism; Pathogenesis; Pathogenicity; Peptides; Pharmaceutical Preparations; Phenotype; Plants; Population; Portraits; Probiotics; Process; Research; Research Personnel; Resistance; Role; Sampling; Sequence Analysis; Sex Attractants; Signaling Molecule; Site; Small RNA; Soil; System; Systems Theory; Technology; Text; Universities; Work; abstracting; base; design; gene discovery; genetic analysis; innovation; luminescence; metabolomics; microbial; microbial community; mutant; novel; pathogen; prevent; professor; response; tool; transcriptomics

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Modulating microbial communities for human health requires understanding the response of communities to invaders, but little is known about the mechanistic bases for community invasion. Our goal is to determine the genetic basis for invasion in the simple model, the gut community of Manduca sexta, and determine the impact of invasion on the meta-metabolome of the host-community complex. We will identify genes involved in invasion and then determine their role in competition and cooperation in the community and their impact on the metabolome to generate hypotheses about the role of signal molecules, antibiotics, and nutrients in community interactions. The project's innovation derives from the marriage of systems-level analysis of metabolite profiles with reductionist genetic analysis, the application of genetics to community-level phenotypes, quantification of microbial populations with luminescence imaging in live animals, and cutting edge chemical technology. The work has the potential to advance the field of microbial community ecology by providing a basis for deriving models about community behavior in the face of perturbation that may apply directly to human health.

在这里输入文本，即应用程序的新抽象信息。这部分不能超过30行