QUANTIFICATION OF FACTORS LEADING TO VEIN GRAFT FAILURE

导致静脉移植失败的因素的量化

• 批准号: 6285915
• 负责人: JOHN C KUCEWICZ
• 金额: $ 38.04万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6285915
• 关键词: angiocardioultrasonography; angiogenesis; atherosclerosis; bioimaging /biomedical imaging; blood flow measurement; blood vessel transplantation; diagnosis design /evaluation; human subject; human therapy evaluation; patient oriented research; restenosis; transplant rejection; veins

DESCRIPTION (Verbatim from the Applicant's Abstract): A 3-dimensional ultrasound imaging method will be developed to provide detailed anatomic and physiologic information about vein bypass grafts which have been placed to restore blood flow past an occluded artery in the leg. This method will replace X-ray contrast angiography and conventional ultrasonic duplex scanning, to provide complete information essential for monitoring the performance of the bypass. The 3-dimensional flow images created by this new method will allow evaluation of the inflow native artery which supplies the blood, the bypass graft, and the outflow native artery that carries the blood on to the foot and other tissues. Changes in the inflow, bypass and outflow segments will be studied over the first year after graft placement. The method will allow the examiner to study normal arterial pathway remodeling as well as the development of pathologic stenoses. More than 100,000 lower extremity bypass grafts are placed in the United States each year. Over 30,000 of these fail within 4 years. By developing methods to detect the early indicators of impending failure, this project offers the opportunity to extend the useful life of the grafts by permitting early treatment of the lesions.

描述（来自申请人摘要的逐字描述）： 超声成像方法将被开发，以提供详细的解剖和 关于静脉旁路移植物的生理信息， 恢复腿部闭塞动脉的血流。该方法将取代 X线造影和常规超声双功扫描， 提供对监测执行情况必不可少的完整信息， 旁路。通过这种新方法创建的三维流动图像将允许 评估供应血液的流入自体动脉、旁路 移植物，以及将血液输送到足部的流出自体动脉， 其他组织。流入段、旁路段和流出段的变化将 在移植后的第一年进行研究。该方法将允许 检查员研究正常动脉通路重塑以及发展 病理性狭窄 在美国，有超过10万例下肢旁路移植术 每年.其中超过30，000个在4年内失败。通过开发方法， 检测即将发生故障的早期指标，该项目提供了 有机会通过允许早期移植来延长移植物的使用寿命 治疗病变。