QUANTIFICATION OF FACTORS LEADING TO VEIN GRAFT FAILURE

描述(逐字摘自申请人的摘要)：一个三维的 将开发超声成像方法，以提供详细的解剖和 静脉旁路移植术后的生理信息 通过腿部闭塞的动脉恢复血液流动。此方法将替换 X线血管造影和常规超声双功扫描，以 提供全面的信息，以监测 旁路。用这种新方法创建的三维流动图像将允许 评价供血的流入动脉的搭桥术 移植物和将血液输送到足部的流出的天然动脉和 其他纸巾。流入段、旁路段和流出段的变化 移植物植入后第一年多学习。该方法将允许 检查员将研究正常动脉通路重塑及其发展 病理性狭窄。 美国安置了超过10万例下肢搭桥手术 每年。其中超过3万家公司在4年内倒闭。通过开发方法来 检测即将发生的故障的早期指标，该项目提供 通过允许及早延长移植物的使用寿命的机会 病变的治疗。

DESCRIPTION (Verbatim from the Applicant's Abstract): A 3-dimensional ultrasound imaging method will be developed to provide detailed anatomic and physiologic information about vein bypass grafts which have been placed to restore blood flow past an occluded artery in the leg. This method will replace X-ray contrast angiography and conventional ultrasonic duplex scanning, to provide complete information essential for monitoring the performance of the bypass. The 3-dimensional flow images created by this new method will allow evaluation of the inflow native artery which supplies the blood, the bypass graft, and the outflow native artery that carries the blood on to the foot and other tissues. Changes in the inflow, bypass and outflow segments will be studied over the first year after graft placement. The method will allow the examiner to study normal arterial pathway remodeling as well as the development of pathologic stenoses. More than 100,000 lower extremity bypass grafts are placed in the United States each year. Over 30,000 of these fail within 4 years. By developing methods to detect the early indicators of impending failure, this project offers the opportunity to extend the useful life of the grafts by permitting early treatment of the lesions.