METABOLIC FACTORS ASSOCIATED WITH LONG-TERM WEIGHT LOSS

候选人冬青·汤普森医学博士致力于追求以患者为导向的临床研究事业。 她目前正在丹佛的科罗拉多大学健康科学中心（UCHSC）完成为期5年的内科和内分泌学临床研究者跟踪。 候选人的长期职业目标是成为肥胖和体重调节领域的独立临床研究者。 她感兴趣的具体领域是在减少肥胖状态和理解机制驱动体重反弹后减肥。 候选人及其导师James Hill博士为候选人制定了职业规划，以培养成为独立临床研究者所需的技能和专业知识。 该计划利用了该机构内存在的许多合作机会和高水平的肥胖专业知识。 她的导师詹姆斯·希尔博士自1982年以来一直成功地资助肥胖研究，是肥胖研究的国际领导者。他完全致力于帮助候选人实现她的职业目标。 候选人提出的研究计划利用了一个独特的注册表，该注册表中的受试者在长期减肥和维持方面取得了成功。 她建议将这些受试者中的一些人（至少5年保持30磅的体重减轻）与体重减轻相似但仅保持减少3个月的人进行比较。 短期体重减轻的受试者被认为是“易感”群体，我们预计大多数人将在1年内恢复体重。相比之下，我们假设已经保持体重减轻5年的受试者不容易体重反弹。 通过比较两组，候选人希望确定可能解释体重反弹易感性的代谢因素。 拟议的项目将为申请人提供进行减肥干预的重要经验，使用先进的工具来评估能量代谢，以及与成功减肥的受试者合作的进一步经验。 这些都是候选人职业规划的重要技能和经验。

The candidate, Holly Thompson M.D., is committed to pursuing a career in patient-oriented clinical research. She currently is completing a 5 year Clinical Investigator Track in Internal Medicine and Endocrinology at the University of Colorado Health Sciences Center (UCHSC) in Denver. The candidate's long-term career goal is to become an independent clinical investigator in the area of obesity and body weight regulation. Her specific area of interest is in the reduced-obese state and in understanding mechanisms driving weight regain following a weight loss. The Candidate and her Mentor, Dr. James Hill, have mapped a career plan for the candidate to develop the skills and expertise necessary to become an independent clinical investigator. This plan takes advantage of the many opportunities for collaborations and the high level of obesity expertise that exists within this institution. Her mentor, Dr. James Hill, has been successfully funded for obesity research since 1982 and is an international leader in obesity research. He is totally committed to helping the candidate achieve her career objectives. The candidate's proposed research plan takes advantage of a unique registry of subjects who have been successful at long term weight loss and maintenance. She proposes to compare some of these subjects (who have maintained a 30 pound weight loss for a minimum of 5 years) to individuals who have lost a similar amount of weight but have only maintained the reduction for 3 months. The short-term weight reduced subjects are assumed to be a "susceptible" group, and we anticipate that most will regain their lost weight within 1 year. In contrast, we assume that subjects who have maintained a weight loss for 5 years are not susceptible to weight regain. By comparing the two groups, the candidate hopes to identify metabolic factors that may explain susceptibility to weight regain. The proposed project will provide the applicant important experience in conducting weight-loss interventions, in the use of sophisticated tools to assess energy metabolism, and further experience in working with successful weight-reduced subjects. These are important skills and experiences for the candidate's career plan.