ENERGY METABOLISM IN REDUCED-OBESE SUBJECTS

该两年期拟议项目旨在了解是否 与对照组相比， 从不肥胖的对照组。该提案的一个主要假设 是减少肥胖不构成一个同质的群体， 能量代谢可能会改变，但不是所有的减少- 肥胖受试者。利用西北铁路，该项目将开始检查 减少肥胖受试者的静息代谢率的决定因素。 一项铝箔ow-up研究将检查总能量消耗（使用 双标记水）的受试者中保持短（1-2 年）与长期（超过5年）体重减轻。最后， 该项目将评估饮食中脂肪氧化反应， 在减少肥胖受试者的操作。没有以前的研究 减少肥胖受试者的能量消耗 与那些保持体重减轻超过5年的人。 事实上，大多数以前减少肥胖的受试者都是在 6个月的减肥。大量的减肥可能会 在能量代谢中产生可能持续很长时间的扰动 一段时间。

The 2-yr proposed project is aimed at understanding whether or not energy metabolism is altered in reduced-obese subjects as compared to never-obese control subjects. A major hypothesis of the proposal is that the reduced-obese do not constitute a homogeneous group and that energy metabolism may be altered in some but not all reduced- obese subjects. Using the NWCR, the project will begin by examining determinants of resting metabolic rate in reduced-obese subjects. A foil ow-up study will examine total energy expenditure (using doubly labeled water) in subjects who have maintained short (1-2 year ) versus long (greater than 5 year) weight reduction. Finally, the project will assess fat oxidation in response to dietary manipulation in reduced-obese subjects. No previous studies of energy expenditure in reduced obese subjects have used subjects with who have maintained their weight loss for longer than 5 years. in fact, most previously reduced-obese subjects were studied within 6 months of their weight loss. Substantial weight loss can likely produce perturbation in energy metabolism that may last for long periods of time.