Digital Multi-channel Tibial Implants in Orthopedic Medicine

数字化多通道胫骨植入物在骨科医学中的应用

基本信息

  • 批准号:
    TS/G002320/1
  • 负责人:
  • 金额:
    $ 54.15万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2009
  • 资助国家:
    英国
  • 起止时间:
    2009 至 无数据
  • 项目状态:
    已结题

项目摘要

Clinical and translational research to develop enhanced treatments for fractures would be greatly facilitated by the use of a valid and reliable measure of fracture healing. In preclinical studies, the gold standard is the measurement of bending or torsional stiffness; these are direct measures of the restitution of the key property of bone. This can only be performed in humans if the fracture is treated conservatively (without fixation) or by means of an external fixator. However the tibial shaft fracture (the fracture most likely to give problems clinically) is most often treated by intramedullary nailing. With an IM nail in situ, stiffness measurement is considered a waste of time, since it reflects the stiffness of the nail, as well as the bone, to an unknown extent. This project aims to overcome that problem by directly measuring strains in the nail in response to well-characterised loading of the bone-nail construct, thus allowing the stiffness of the bone itself to be deduced.The alternative approach to the monitoring of fracture healing is by radiographic imaging. With conventional radiographs this is apt to be misleading, though that is what clinicians use on a day-to-day basis. In this study, 3-D images from spiral CT will be processed by finite element analysis (FEA) to calculate the strength and stiffness of the healing fracture and this technique (which would not be realistic for routine use) will be used to validate the results obtained by the new telemetric method.We will take modified tibial nails, 11mm in diameter, supplied by our industrial partner and instrument them with 36 strain gauges distributed at three circumferential sites at three levels, together with the circuitry to read the strains and transmit them as radio waves. The electronics will be powered inductively through a coil enclosed in a ceramic ring on the end of the nail, preserving the cannulation of the whole nail which allows its insertion over a guide wire. Each instrumented nail will be calibrated to allow measurement of force with six degrees of freedom, and also bending deflection.Nails of several appropriate lengths will be instrumented for insertion into nine patients who are having surgery for delayed union of tibial shaft fractures, with a variety of fracture configurations at different levels in the tibia. The nails will be double-locked top and bottom with threaded screws so that the mechanical link between nail and bone will be rigid. At intervals following surgery we will examine the patients by gait analysis with simultaneous telemetric readings of strain from the nail. A 3D lower limb biomechanical model will be developed to allow the determination of forces acting on the tibia-nail construct, taking into account the forces generated in the construct by the patient's muscles. The forces and deflections experienced by the nail will be processed to yield the contribution of the bone to the whole construct. Simpler static loading protocols will also be explored. At the same time points, spiral CT images of 0.3mm slice thickness will be acquired and the datasets used to feed material properties of the bone and fracture callus into FEA software, excluding the nail, from which structural stiffness of the healing bone will be calculated. We will also apply validated scales of lower limb function.Using the FEA-derived structural properties of the bone as our comparator, we will validate the stiffness measurement based on analysis of the nail readout and loads. We will then use principal component analysis to determine the minimal strain gauge configuration and simplest loading protocols that yield sufficient information, in order to refine the system for commercialisation and clinical use. As well as providing an outcome measure for clinical trials, the system will be useful in routine treatment to guide rehabilitation and receive earlier warning of the need for secondary interventions such as bone graft.
通过使用有效和可靠的骨折愈合措施,将大大促进开发骨折强化治疗的临床和转化研究。在临床前研究中,金标准是弯曲或扭转刚度的测量;这些是骨关键特性恢复的直接测量。这只能在人类中进行,如果骨折保守治疗(不固定)或通过外固定器。然而,胫骨干骨折(最有可能给临床带来问题的骨折)最常采用髓内钉治疗。对于原位髓内钉,刚度测量被认为是浪费时间,因为它反映了髓内钉以及骨的刚度,但程度未知。该项目旨在通过直接测量髓内钉中的应变来克服这一问题,以响应骨-髓内钉结构的良好表征的负载,从而允许推断骨本身的刚度。传统的X光片容易产生误导,尽管这是临床医生日常使用的方法。在这项研究中,螺旋CT的三维图像将通过有限元分析(FEA)来处理,以计算愈合骨折的强度和刚度,(这对于常规使用是不现实的)将被用来验证新的遥测方法获得的结果。我们将采取改良的胫骨钉,直径11 mm,由我们的工业合作伙伴提供,并在三个水平的三个圆周位置分布36个应变计,以及读取应变并将其作为无线电波传输的电路。电子设备将通过封闭在髓内钉末端陶瓷环中的线圈感应供电,保留整个髓内钉的套管,允许其沿导丝插入。将对每个内固定髓内钉进行校准,以允许测量六个自由度的力,以及弯曲挠度。将使用几种适当长度的髓内钉插入9名因胫骨干骨折延迟愈合而接受手术的患者体内,这些患者在胫骨的不同水平具有各种骨折构型。髓内钉将在顶部和底部用螺纹螺钉双重锁定,以便髓内钉和骨之间的机械连接将是刚性的。在手术后的间隔,我们将检查患者的步态分析,同时遥测读数的应变从指甲。将开发3D下肢生物力学模型,以确定作用于胫骨髓内钉结构的力,同时考虑患者肌肉在结构中产生的力。将处理髓内钉所经受的力和偏转,以产生骨对整个结构的贡献。还将探讨更简单的静态加载协议。在同一时间点,将采集0.3 mm层厚的螺旋CT图像,并将数据集用于将骨和骨折骨痂的材料特性输入FEA软件(髓内钉除外),从中计算愈合骨的结构刚度。我们还将应用经过验证的下肢功能量表。使用FEA导出的骨结构特性作为比较器,我们将根据髓内钉读数和载荷分析来验证刚度测量。然后,我们将使用主成分分析来确定最小的应变片配置和最简单的加载协议,以产生足够的信息,以完善系统的商业化和临床使用。除了为临床试验提供结果测量外,该系统还将用于常规治疗,以指导康复并提前收到需要进行二次干预(如骨移植)的警告。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Strain response of an instrumented intramedullary nail to three-point bending.
仪器化髓内钉对三点弯曲的应变响应。
D-4 Biomechanical Fracture Healing Simulation for Smart Implants Using Telemetry
D-4 使用遥测技术进行智能植入物的生物力学骨折愈合模拟
  • DOI:
    10.1016/s0021-9290(10)70155-x
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Nemchand J
  • 通讯作者:
    Nemchand J
SCIMITAR: subject-carried implant monitoring inductive telemetric ambulatory reader for remote data acquisition from implanted orthopaedic prostheses.
SCIMITAR:受试者携带的植入物监测感应式遥测移动阅读器,用于从植入的矫形假体远程采集数据。
  • DOI:
    10.1016/j.medengphy.2013.09.001
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Hao S
  • 通讯作者:
    Hao S
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Stephen Taylor其他文献

A Hausdorff measure classification of polar sets for the heat equation
热方程极集的豪斯多夫测度分类
The long shadows cast by the field: violence, trauma, and the ethnographic researcher
该领域投下的长长的阴影:暴力、创伤和民族志研究者
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Taylor
  • 通讯作者:
    Stephen Taylor
A quantitative investigation of electron detrapping in SiO2 under Fowler–Nordheim stress
Fowler-Nordheim 应力下 SiO2 中电子去俘获的定量研究
  • DOI:
    10.1063/1.350452
  • 发表时间:
    1992
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    J. Zhang;Stephen Taylor;W. Eccleston
  • 通讯作者:
    W. Eccleston
Can Virtual Replace In-person Coaching? Experimental Evidence on Teacher Professional Development and Student Learning in South Africa
虚拟辅导可以取代面对面辅导吗?
FITC-lectin avidity of Cryptococcus neoformans cell wall and capsular components
新型隐球菌细胞壁和荚膜成分的 FITC-凝集素亲合力
  • DOI:
    10.1080/15572536.2005.11832989
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    A. J. Foster;R. Bird;S. Kelly;K. Nishimura;David A. Poyner;Stephen Taylor;Stephen N. Smith
  • 通讯作者:
    Stephen N. Smith

Stephen Taylor的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Stephen Taylor', 18)}}的其他基金

High-grade serous ovarian cancer: exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability
高级别浆液性卵巢癌:利用活生物库来描述疾病特异性染色体不稳定的机制
  • 批准号:
    MR/X008088/1
  • 财政年份:
    2023
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grant
WoU-MMA: Mapping the host galaxies of low-frequency gravitational-wave sources
WoU-MMA:绘制低频引力波源的主星系图
  • 批准号:
    2307719
  • 财政年份:
    2023
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Standard Grant
CAREER: Unveiling the Nanohertz GW Discovery Landscape by Broadening Participation In Multi-Messenger Astrophysics
职业生涯:通过扩大多信使天体物理学的参与来揭示纳赫兹引力波发现景观
  • 批准号:
    2146016
  • 财政年份:
    2021
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Continuing Grant
WoU-MMA: Multi-messenger Titans: Probing The Dynamics & Environments Of Supermassive Binary Black Holes
WoU-MMA:多信使泰坦:探索动态
  • 批准号:
    2007993
  • 财政年份:
    2020
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Standard Grant
Cultural Heritage 360
文化遗产360
  • 批准号:
    AH/V005596/1
  • 财政年份:
    2020
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grant
Non-genetic heterogeneity in response to anti-mitotic chemotherapeutics
抗有丝分裂化疗药物反应的非遗传异质性
  • 批准号:
    MR/L006839/1
  • 财政年份:
    2014
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grant
Hawaii-Vancouver Education, Assessment, and Articulation Planning Visit: Vancouver, Canada, July-August 2009
夏威夷-温哥华教育、评估和衔接规划访问:加拿大温哥华,2009 年 7 月至 8 月
  • 批准号:
    0938979
  • 财政年份:
    2009
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Standard Grant
Microengineering of Quadrupole Mass Spectrometers using RP techniques
使用 RP 技术的四极杆质谱仪微工程
  • 批准号:
    EP/F008848/1
  • 财政年份:
    2007
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grant
The role of Cenp-F and Nudel in chromosome segregation
Cenp-F 和 Nudel 在染色体分离中的作用
  • 批准号:
    BB/E015034/1
  • 财政年份:
    2007
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grant
Research Experiences for Undergraduates in Chemistry at Hope College
希望学院化学专业本科生的研究经历
  • 批准号:
    9619667
  • 财政年份:
    1997
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Continuing Grant

相似国自然基金

基于Multi-Pass Cell的高功率皮秒激光脉冲非线性压缩关键技术研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
Multi-decadeurbansubsidencemonitoringwithmulti-temporaryPStechnique
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    80 万元
  • 项目类别:
High-precision force-reflected bilateral teleoperation of multi-DOF hydraulic robotic manipulators
  • 批准号:
    52111530069
  • 批准年份:
    2021
  • 资助金额:
    10 万元
  • 项目类别:
    国际(地区)合作与交流项目
基于8色荧光标记的Multi-InDel复合检测体系在降解混合检材鉴定的应用研究
  • 批准号:
  • 批准年份:
    2021
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
大规模非确定图数据分析及其Multi-Accelerator并行系统架构研究
  • 批准号:
    62002350
  • 批准年份:
    2020
  • 资助金额:
    24.0 万元
  • 项目类别:
    青年科学基金项目
3D multi-parameters CEST联合DKI对椎间盘退变机制中微环境微结构改变的定量研究
  • 批准号:
    82001782
  • 批准年份:
    2020
  • 资助金额:
    24.0 万元
  • 项目类别:
    青年科学基金项目
高速Multi-bit/cycle SAR ADC性能优化理论研究
  • 批准号:
    62004023
  • 批准年份:
    2020
  • 资助金额:
    24.0 万元
  • 项目类别:
    青年科学基金项目
基于multi-SNP标记及不拆分策略的复杂混合样本身份溯源研究
  • 批准号:
  • 批准年份:
    2020
  • 资助金额:
    56 万元
  • 项目类别:
    面上项目
大地电磁强噪音压制的Multi-RRMC技术及其在青藏高原东南缘—印支块体地壳流追踪中的应用
  • 批准号:
  • 批准年份:
    2020
  • 资助金额:
    万元
  • 项目类别:
    国际(地区)合作与交流项目

相似海外基金

Proposal and demonstration of OFDM terrestrial digital signal multi-channel batch conversion method for emergency CATV broadcasting such as tsunami flood
海啸洪水等紧急CATV广播的OFDM地面数字信号多频道批量转换方法的提出和论证
  • 批准号:
    17K06421
  • 财政年份:
    2017
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Innovative Multi-Channel Platform for Digital Applications in the Retail Sector
适用于零售行业数字应用的创新多渠道平台
  • 批准号:
    720329
  • 财政年份:
    2013
  • 资助金额:
    $ 54.15万
  • 项目类别:
    GRD Development of Prototype
Digital Multi-channel Tibial Implants in Orthopedic Medicine
数字化多通道胫骨植入物在骨科医学中的应用
  • 批准号:
    100562
  • 财政年份:
    2008
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Collaborative R&D
Multi-channel digital oscilloscope and logical analyzer for the multi-event injection analysis of diesel engines
用于柴油发动机多事件喷射分析的多通道数字示波器和逻辑分析仪
  • 批准号:
    359534-2008
  • 财政年份:
    2007
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Tools and Instruments - Category 1 (<$150,000)
Multi-channel reconfigurable high dynamic range digital receivers
多通道可重构高动态范围数字接收器
  • 批准号:
    ARC : LP0219662
  • 财政年份:
    2002
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Linkage Projects
Digital four channel, multi-frequency radio-acoustic positioning and telemetry system (RAPT)
数字四通道、多频无线电声定位和遥测系统 (RAPT)
  • 批准号:
    228907-2000
  • 财政年份:
    1999
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Tools and Instruments - Category 1 (<$150,000)
Bit - rate reduction of multi-channel high quality digital audio signals
多通道高质量数字音频信号的比特率降低
  • 批准号:
    46756-1992
  • 财政年份:
    1994
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Discovery Grants Program - Individual
Bit - rate reduction of multi-channel high quality digital audio signals
多通道高质量数字音频信号的比特率降低
  • 批准号:
    46756-1992
  • 财政年份:
    1993
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Discovery Grants Program - Individual
Bit - rate reduction of multi-channel high quality digital audio signals
多通道高质量数字音频信号的比特率降低
  • 批准号:
    46756-1992
  • 财政年份:
    1992
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Discovery Grants Program - Individual
DIGIPART: Digital solution of participation deficits? Multi-channel-participation at the three critical interfaces of the planning process
DIGIPART:参与赤字的数字解决方案?
  • 批准号:
    468523613
  • 财政年份:
  • 资助金额:
    $ 54.15万
  • 项目类别:
    Research Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了