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Studies of interaction between psychological state and food intake on gastrointestinal motility, splanchnic perfusion and autonomic nervous system in

心理状态与食物摄入对胃肠动力、内脏灌注和自主神经系统相互作用的研究

基本信息

批准号：
1618761
负责人：
金额：
--
依托单位：
Queen Mary University of London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1618761
关键词：
Studies interaction between psychological state

项目摘要

Abstract A relationship between psychological state such as stress and emotions and feeding behaviour is known to exist, and yet the physiological basis of this interaction remains incompletely understood. It appears likely that the physiological stress response systems such as the autonomic nervous system, Hypothalamic Pituitary Adrenal (HPA) Axis and satiety hormones play an important modulatory role in this relationship. Previous research has focused on isolated GI sensory-motor responses and relied upon subjective symptom reports or investigations that require intubation or exposure to ionising radiation to assess key physiological processes involved in digestion. The primary aim of this PhD project is to validate novel computational approaches and advanced imaging techniques in both human and preclinical rodent models to measure these simultaneously and minimally invasively. Validation of these methods would provide further insight into physiological mechanisms in health and disease; enable the stratification of patients who present with similar symptoms (e.g. dyspepsia) but different underlying pathologies (e.g. altered motility, altered accommodation, altered splanchnic circulation); provide an objective way of determining treatment response in clinical trials; and support the identification of novel biomarkers and therapeutic targets. Nutrient and drug challenges will be used to provoke changes in appetite-related sensations and upper GI symptoms and their effect on the autonomic nervous system (using heart rate and respiratory variability) and gastrointestinal motility (using magnetic resonance imaging, MRI) in healthy human subjects. The interaction between these parameters and personality traits, body perception and emotional state will be characterised using validated questionnaires and assessments to better understand the complex interface between psychological and physiological processes. In vivo imaging of gastrointestinal transit will also be applied to rodent models of accelerated or delayed transit.

摘要压力、情绪等心理状态与摄食行为之间的关系已为人所知，但这种相互作用的生理基础仍不完全清楚。在这种关系中，自主神经系统、下丘脑-垂体-肾上腺(HPA)轴和饱腹感激素等生理应激反应系统可能起着重要的调节作用。以前的研究侧重于孤立的GI感觉-运动反应，并依赖于主观症状报告或需要插管或暴露在电离辐射中的调查来评估涉及消化的关键生理过程。该博士项目的主要目的是在人类和临床前啮齿动物模型中验证新的计算方法和先进的成像技术，以同时以最小的侵入性测量这些方法。这些方法的验证将提供对健康和疾病中的生理机制的进一步了解；能够对出现类似症状(例如消化不良)但具有不同潜在病理(例如运动能力改变、调节改变、内脏循环改变)的患者进行分层；提供在临床试验中确定治疗反应的客观方法；并支持确定新的生物标志物和治疗靶点。营养和药物挑战将被用来引起与食欲相关的感觉和上消化道症状的变化，以及它们对健康受试者自主神经系统(使用心率和呼吸变异性)和胃肠动力(使用磁共振成像)的影响。这些参数与人格特征、身体知觉和情绪状态之间的相互作用将通过有效的问卷和评估来表征，以更好地理解心理和生理过程之间的复杂接口。胃肠道转运的活体成像也将应用于加速或延迟转运的啮齿动物模型。