ANALYSIS OF STRUCTURE-FROM-MOTION IN VISUAL CORTEX

描述：(改编自《调查员摘要》)：本提案 首次对7a区的皮质地形进行系统分析 在行为正常的猴子的顶下小叶。重点放在 揭示多种视觉、动眼和空间的分布 7a区范围内的申述。创新的组合 本征光学成像、单单元记录和解剖示踪方法 将用于在多个级别的解决方案中解决这些问题。 对猴顶下小叶7a区的认识 开始进入平台期。从单个单位对该地区的研究中可以很好地确定这一点 7A神经元代表视觉和眼睛位置信息，以及 注意力集中的状态。然而，人们对这些性质是如何产生的知之甚少 分布在大脑皮层上，或者这些分布的表示是如何 因行为而改变。7a区的空间表达：探索这些 问题、光流(例如径向、平面旋转、平移)和亮度 当动物盯着不同的位置时，刺激会被呈现出来 反应时间任务中的视野。许多品质改变了 7a区神经元的反应，如速度和视差，以及收敛 系统地处理以确定分布的 申述。将使用本征信号的光学成像来映射 视网膜的地形图，眼睛的位置，和头部中心的位置 行为正常的猴子的皮质表面。将使用单一单元研究来 验证光学成像的结果。两者之间的关系 联合和联合投影以及光学记录的地图将是 决心核实地图本身，以及了解 分发的信号被传输到接收区。注意调节 猴子的注意力状态将被改变，以确定是否 皮质表示是可塑性的，即它可以在 皮质表面。光学测量的组合，单个单元 记录和解剖可以描述正常顶叶空间的特征 功能。这些研究将对正确选择哪个顶叶至关重要 当存在空间时，最好通过治疗来修改表示 由中风造成的顶叶损害造成的人类受试者缺陷。

DESCRIPTION: (Adapted from the Investigator's Abstract): This proposal undertakes the first systematic analysis of the cortical topography of area 7a of the inferior parietal lobule in the behaving monkey. The focus is on uncovering the distribution of multiple visual, oculomotor and spatial representations across the extent of area 7a. An innovative combination of intrinsic optical imaging, single unit recordings and anatomical tracer methods will be used to address these issues at multiple levels of resolution. Understanding of area 7a in the inferior parietal lobule of the monkey is beginning to plateau. It is well established from single unit studies that area 7a neurons represent visual and eye position information, as well as attentional state. However little is known as to how these properties are distributed across the cortex, or how these distributed representations are modified by behavior. Spatial representations in area 7a: To explore these issues, optic flow (e.g. radial, planar rotational, translation) and luminance stimuli will be presented while the animal fixates on different locations in the visual field in a reaction time task. Many qualities that alter the response of area 7a neurons, such as speed and disparity, and vergence will be systematically manipulated to determine the dependence of the distributed representations. Optical imaging of the intrinsic signal will be used to map the topography of retinal, eye position, and head-centered location across the cortical surface in the behaving monkey. Single unit studies will be used to verify the results of the optical imaging. The relationships between both associational and collosal projections and the optically recorded maps will be determined to verify the maps themselves, as well as to understand how the distributed signals are transmitted to recipient areas. Attentional modulation of maps: The monkeys'attentional state will be altered to determine whether the cortical representation is plastic, i.e. it can be transformed across the cortical surface. The combination of optical measurements, single unit recording, and anatomy allows characterization of normal parietal spatial function. These studies will be crucial in correctly choosing which parietal representations are best modified through therapy when there are spatial deficits in human subjects caused by parietal damage through stroke.