ANALYSIS OF STRUCTURE-FROM-MOTION IN VISUAL CORTEX

描述：（改编自研究者摘要）：本提案 首次对7a区的皮层地形进行了系统分析 顶叶下小叶的位置。重点是 揭示多种视觉、视觉和空间的分布， 在整个区域7a的范围上的表示。创新的组合， 内在光学成像、单个单位记录和解剖示踪方法 将用于在多个分辨率级别上解决这些问题。 对猴顶下小叶7a区的理解是 开始进入高原。从单个单元研究中可以很好地确定， 7a神经元代表视觉和眼睛位置信息，以及 注意力状态然而，人们对这些特性是如何产生的知之甚少。 分布在大脑皮层，或者这些分布的表征是如何 被行为所改变区域7a中的空间表征：为了探索这些 问题、光流（例如，径向、平面旋转、平移）和亮度 当动物注视不同位置时， 在反应时间任务中的视野。许多品质改变了 区域7a神经元的反应，如速度和视差，以及聚散度将被 系统地操纵，以确定分布的 表示。本征信号的光学成像将用于映射 视网膜的地形图，眼睛的位置，和头为中心的位置跨越 大脑皮层表面。单单位研究将用于 验证光学成像的结果。两者之间的关系 联合和collosal投影和光学记录的地图将是 决心验证地图本身，以及了解如何 分布式信号被发送到接收区域。注意调制 猴子的注意力状态将被改变，以确定 皮质表示是可塑的，即它可以在整个 皮质表面光学测量的组合，单个单元 记录和解剖允许正常顶叶空间的表征 功能这些研究对于正确选择哪种顶骨至关重要 当存在空间障碍时， 人类受试者因中风造成的顶叶损伤而导致的缺陷。

DESCRIPTION: (Adapted from the Investigator's Abstract): This proposal undertakes the first systematic analysis of the cortical topography of area 7a of the inferior parietal lobule in the behaving monkey. The focus is on uncovering the distribution of multiple visual, oculomotor and spatial representations across the extent of area 7a. An innovative combination of intrinsic optical imaging, single unit recordings and anatomical tracer methods will be used to address these issues at multiple levels of resolution. Understanding of area 7a in the inferior parietal lobule of the monkey is beginning to plateau. It is well established from single unit studies that area 7a neurons represent visual and eye position information, as well as attentional state. However little is known as to how these properties are distributed across the cortex, or how these distributed representations are modified by behavior. Spatial representations in area 7a: To explore these issues, optic flow (e.g. radial, planar rotational, translation) and luminance stimuli will be presented while the animal fixates on different locations in the visual field in a reaction time task. Many qualities that alter the response of area 7a neurons, such as speed and disparity, and vergence will be systematically manipulated to determine the dependence of the distributed representations. Optical imaging of the intrinsic signal will be used to map the topography of retinal, eye position, and head-centered location across the cortical surface in the behaving monkey. Single unit studies will be used to verify the results of the optical imaging. The relationships between both associational and collosal projections and the optically recorded maps will be determined to verify the maps themselves, as well as to understand how the distributed signals are transmitted to recipient areas. Attentional modulation of maps: The monkeys'attentional state will be altered to determine whether the cortical representation is plastic, i.e. it can be transformed across the cortical surface. The combination of optical measurements, single unit recording, and anatomy allows characterization of normal parietal spatial function. These studies will be crucial in correctly choosing which parietal representations are best modified through therapy when there are spatial deficits in human subjects caused by parietal damage through stroke.