ANALYSIS OF STRUCTURE-FROM-MOTION IN VISUAL CORTEX

描述：（改编自研究者摘要）：本提案 对 7a 区的皮质地形进行首次系统分析 行为猴的顶下小叶。重点是 揭示多重视觉、动眼神经和空间的分布 7a 区域范围内的代表。创新组合 内在光学成像、单个单元记录和解剖示踪方法 将用于在多个分辨率级别上解决这些问题。 对猴子顶下小叶7a区的理解是 开始趋于平稳。从单个单元研究中可以看出，该领域 7a 神经元代表视觉和眼睛位置信息，以及 注意力状态。然而，人们对这些属性是如何了解的却知之甚少。 分布在整个皮层，或者这些分布的表示是如何分布的 通过行为改变。区域 7a 中的空间表示：探索这些 问题、光流（例如径向、平面旋转、平移）和亮度 当动物注视不同位置时会出现刺激 反应时间任务中的视野。许多品质改变了 7a 区神经元的反应，例如速度、视差和聚散度将是 系统地操纵以确定分布式的依赖性 交涉。固有信号的光学成像将用于映射 视网膜的地形、眼睛的位置和以头部为中心的位置 行为猴子的皮质表面。单一单元研究将用于 验证光学成像的结果。两者之间的关系 关联投影和体投影以及光学记录的地图将被 决心验证地图本身，并了解如何 分布式信号被传输到接收区域。注意力调节 地图：猴子的注意力状态将被改变以确定是否 皮质表征是可塑的，即它可以在整个 皮质表面。光学测量的组合，单一单元 记录和解剖学允许表征正常顶叶空间 功能。这些研究对于正确选择哪种顶叶至关重要 当存在空间问题时，最好通过治疗来修改表征 人类受试者因中风造成的顶骨损伤而导致的缺陷。

DESCRIPTION: (Adapted from the Investigator's Abstract): This proposal undertakes the first systematic analysis of the cortical topography of area 7a of the inferior parietal lobule in the behaving monkey. The focus is on uncovering the distribution of multiple visual, oculomotor and spatial representations across the extent of area 7a. An innovative combination of intrinsic optical imaging, single unit recordings and anatomical tracer methods will be used to address these issues at multiple levels of resolution. Understanding of area 7a in the inferior parietal lobule of the monkey is beginning to plateau. It is well established from single unit studies that area 7a neurons represent visual and eye position information, as well as attentional state. However little is known as to how these properties are distributed across the cortex, or how these distributed representations are modified by behavior. Spatial representations in area 7a: To explore these issues, optic flow (e.g. radial, planar rotational, translation) and luminance stimuli will be presented while the animal fixates on different locations in the visual field in a reaction time task. Many qualities that alter the response of area 7a neurons, such as speed and disparity, and vergence will be systematically manipulated to determine the dependence of the distributed representations. Optical imaging of the intrinsic signal will be used to map the topography of retinal, eye position, and head-centered location across the cortical surface in the behaving monkey. Single unit studies will be used to verify the results of the optical imaging. The relationships between both associational and collosal projections and the optically recorded maps will be determined to verify the maps themselves, as well as to understand how the distributed signals are transmitted to recipient areas. Attentional modulation of maps: The monkeys'attentional state will be altered to determine whether the cortical representation is plastic, i.e. it can be transformed across the cortical surface. The combination of optical measurements, single unit recording, and anatomy allows characterization of normal parietal spatial function. These studies will be crucial in correctly choosing which parietal representations are best modified through therapy when there are spatial deficits in human subjects caused by parietal damage through stroke.