IONOPHORE-BASED CHEMICAL ION SENSORS

基于离子载体的化学离子传感器

• 批准号: 6351270
• 负责人: ERIC BAKKER
• 金额: $ 9.2万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351270
• 关键词: biomedical equipment development; biosensor device; electrodes; ionophores; ions; potentiometry

This research develops novel, general, and convenient methodologies to characterize ionophores and sensor materials relevant to optical, potentiometric and voltammetric transduction schemes. These ionophore- based chemical sensors are vital components in clinical, physiological, and biomedical environments. The use of polymeric membranes containing two competing ionophores to assess the strength of ion-ionophore interactions directly within the sensing film is established. These measurements are accomplished with an optical and potentiometric technique which are rigorously compared to each other. Influences of different types and concentrations of ionophores, reference ionophores, ionic sites, and membrane matrices/plasticizer are studied to give information on complex formation constants, complex stoichiometry, and extent of ion compatible solvents as a described comparative method. Methods are designed to characterize anion responsive ionophores by utilizing and characterizing electrically charged H+-ionophores. The method is applied to a large selection of established and novel ionophores embedded in a variety of matrices, and the results are compared to the analytical characteristics of the respective chemical transduction scheme. The potentiometric behavior of solid contact membrane electrodes is quantitative characterized as a possible alternative approach to two-ionophore systems. Membrane-internal diffusion potential profiles are directly mapped with an array of modified metal electrodes by interposing them within ion-selective electrode membranes, thereby elucidating the source of possible membrane instabilities and potential drifts.

本研究开发了新颖、通用和方便的方法

项目成果

Effect of lipophilic ion-exchanger leaching on the detection limit of carrier-based ion-selective electrodes.

• DOI: 10.1021/ac010526h
• 发表时间: 2001-10
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: Martin Telting-Diaz and;Eric Bakker

Quantification of the concentration of ionic impurities in polymeric sensing membranes with the segmented sandwich technique.

使用分段夹心技术定量聚合物传感膜中离子杂质的浓度。

• DOI: 10.1021/ac0104126
• 发表时间: 2001
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: Qin,Y;Bakker,E
• 通讯作者: Bakker,E

Renewable pH cross-sensitive potentiometric heparin sensors with incorporated electrically charged H+ ionophores.

• DOI: 10.1021/ac990387s
• 发表时间: 1999-09
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: S. Mathison;E. Bakker

Direct potentiometric information on total ionic concentrations.

• DOI: 10.1021/ac991092h
• 发表时间: 2000-05
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: A. Ceresa;E. Pretsch;E. Bakker

Perbrominated closo-dodecacarborane anion, 1-HCB11Br11-, as an ion exchanger in cation-selective chemical sensors.

• DOI: 10.1021/ac0156262
• 发表时间: 2002-02
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: S. Peper;M. Telting-Diaz;P. Almond;T. Albrecht‐Schmitt;E. Bakker