Holistic face processing--Inputs and origins

整体人脸处理——输入和起源

• 批准号: 6405274
• 负责人: BRADLEY C DUCHAINE
• 金额: $ 3.33万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-12 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6405274
• 关键词: clinical research; face; gender difference; human subject; learning; visual perception

Pulmonary rehabilitation has become increasingly well established as a standard of care for patients with chronic lung diseases. Despite the expanding body of scientific evidence demonstrating benefits of such programs, there are several important issues that need further investigation. First, few of the published studies have long-term follow- up beyond six months. The value of pulmonary rehabilitation will be limited unless the effects can be captured and quantified over longer periods of time. Second, the literature does not clearly identify the relationship of physiologic and other symptom or health status measures such as health related quality of life (HRQOL) as outcome measures. Third, the quality-adjusted life year (QALY) concept is becoming important in medical and health services research. However, there are no studies that systematically measure QALYs over time in patients with chronic lung disease. This proposal will provide important information about long-term outcomes in pulmonary rehabilitation, incorporating analyses with HRQOL and QALY data. The 1 st phase of this study will compare and contrast general and disease-specific measures obtained as part of an existing clinical trial of maintenance therapy after pulmonary rehabilitation in a cohort of patients with chronic obstructive pulmonary disease. The 2nd phase will obtain new data from a 5-7 year follow-up of this same cohort in order to evaluate long-term: (a) changes in HRQOL. spirometry, and survival; and (b) predictors of survival and OALYs.

肺康复已经越来越好地确立为慢性肺部疾病患者的护理标准。尽管越来越多的科学证据证明了这些计划的好处，但仍有几个重要问题需要进一步调查。首先，已发表的研究很少有超过六个月的长期随访。肺康复的价值将是有限的，除非效果可以在较长的时间内捕获和量化。其次，文献没有明确确定生理和其他症状或健康状况指标（如健康相关生活质量（HRQOL））作为结局指标的关系。第三，质量调整生命年（QALY）概念在医疗卫生服务研究中变得越来越重要。然而，没有研究系统地测量慢性肺部疾病患者随时间的QT。该建议将提供有关肺康复长期结局的重要信息，并结合HRQOL和QALY数据进行分析。本研究的第1阶段将比较和对比作为现有慢性阻塞性肺疾病患者队列肺康复后维持治疗临床试验的一部分获得的一般和疾病特异性指标。第二阶段将从同一队列的5-7年随访中获得新数据，以评价长期：（a）HRQOL的变化。肺量测定法和存活率;和（B）存活率和肺功能的预测因子。