Holistic face processing--Inputs and origins

肺康复作为慢性肺部疾病患者的一种标准治疗方法已经越来越成熟。尽管越来越多的科学证据证明这些项目的好处，但仍有几个重要的问题需要进一步调查。首先，发表的研究中很少有超过6个月的长期随访。肺康复的价值将是有限的，除非效果可以在较长时间内被捕获和量化。其次，文献没有明确地确定生理和其他症状或健康状况测量的关系，如健康相关生活质量（HRQOL）作为结果测量。第三，质量调整生命年（QALY）概念在医疗卫生服务研究中越来越重要。然而，没有研究系统地测量慢性肺病患者的QALYs随时间的变化。该建议将结合HRQOL和QALY数据分析，提供关于肺康复长期预后的重要信息。本研究的第一阶段将比较和对比慢性阻塞性肺病患者队列肺康复后维持治疗的现有临床试验中获得的一般和疾病特异性措施。第二阶段将从同一队列的5-7年随访中获得新的数据，以评估长期：(a) HRQOL的变化。肺活量测定和生存率；(b)生存和OALYs的预测因子。

Pulmonary rehabilitation has become increasingly well established as a standard of care for patients with chronic lung diseases. Despite the expanding body of scientific evidence demonstrating benefits of such programs, there are several important issues that need further investigation. First, few of the published studies have long-term follow- up beyond six months. The value of pulmonary rehabilitation will be limited unless the effects can be captured and quantified over longer periods of time. Second, the literature does not clearly identify the relationship of physiologic and other symptom or health status measures such as health related quality of life (HRQOL) as outcome measures. Third, the quality-adjusted life year (QALY) concept is becoming important in medical and health services research. However, there are no studies that systematically measure QALYs over time in patients with chronic lung disease. This proposal will provide important information about long-term outcomes in pulmonary rehabilitation, incorporating analyses with HRQOL and QALY data. The 1 st phase of this study will compare and contrast general and disease-specific measures obtained as part of an existing clinical trial of maintenance therapy after pulmonary rehabilitation in a cohort of patients with chronic obstructive pulmonary disease. The 2nd phase will obtain new data from a 5-7 year follow-up of this same cohort in order to evaluate long-term: (a) changes in HRQOL. spirometry, and survival; and (b) predictors of survival and OALYs.