Holistic face processing--Inputs and origins

肺康复已日益成为慢性肺部疾病患者护理的标准。尽管越来越多的科学证据证明了这类计划的好处，但仍有几个重要问题需要进一步调查。首先，发表的研究中很少有长期随访超过6个月的。肺康复的价值将是有限的，除非其影响能够在更长的时间内被捕捉和量化。其次，文献没有明确指出生理和其他症状或健康状况指标的关系，如健康相关生活质量(HRQOL)作为结果指标。第三，质量调整生命年(QALY)的概念在医疗卫生服务研究中变得越来越重要。然而，没有研究系统地测量慢性肺病患者随着时间的推移的QALY。该建议将结合HRQOL和QALY数据的分析，提供有关肺康复的长期结果的重要信息。这项研究的第一阶段将比较和对比作为慢性阻塞性肺疾病患者队列患者肺康复后维持治疗的现有临床试验的一部分而获得的一般措施和疾病特异性措施。第二阶段将从同一队列的5-7年随访中获得新的数据，以评估长期：(A)HRQOL的变化。肺活量测定和存活率；以及(B)存活率和OALY的预测因子。

Pulmonary rehabilitation has become increasingly well established as a standard of care for patients with chronic lung diseases. Despite the expanding body of scientific evidence demonstrating benefits of such programs, there are several important issues that need further investigation. First, few of the published studies have long-term follow- up beyond six months. The value of pulmonary rehabilitation will be limited unless the effects can be captured and quantified over longer periods of time. Second, the literature does not clearly identify the relationship of physiologic and other symptom or health status measures such as health related quality of life (HRQOL) as outcome measures. Third, the quality-adjusted life year (QALY) concept is becoming important in medical and health services research. However, there are no studies that systematically measure QALYs over time in patients with chronic lung disease. This proposal will provide important information about long-term outcomes in pulmonary rehabilitation, incorporating analyses with HRQOL and QALY data. The 1 st phase of this study will compare and contrast general and disease-specific measures obtained as part of an existing clinical trial of maintenance therapy after pulmonary rehabilitation in a cohort of patients with chronic obstructive pulmonary disease. The 2nd phase will obtain new data from a 5-7 year follow-up of this same cohort in order to evaluate long-term: (a) changes in HRQOL. spirometry, and survival; and (b) predictors of survival and OALYs.