Attaching Graphene to Surfaces for Antimicrobial Applications

将石墨烯附着到表面以用于抗菌应用

• 批准号: 1745307
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1745307
• 关键词: Attaching; Graphene; Surfaces; Antimicrobial; Applications

Over the past few years there have been many interesting results in the literature about the interaction of graphene (G) and graphene oxide (GO) with microorganisms. However, the results seen so far are inconsistent. The literature has reported varying degrees of biocompatibility and selectivity for the two materials but it is widely believed that they are both bactericidal. This wide range of reported activity is likely due there being a number of mechanisms by which graphene-type materials can act on cells including: inducing oxidative stress; disrupting membranes due to sharp edges; delivering adsorbed impurities; greatly changing substrate stiffness and roughness.In this project, we will make novel nanocomposite surfaces using surface-grafted polymer brush chains with adsorbed graphene and graphene oxide. We will test literature hypotheses regarding the interaction of graphene and cells, with the aim of producing selective antimicrobial coatings.

在过去的几年中，在关于石墨烯（G）和氧化石墨烯（GO）与微生物的相互作用的文献中有许多有趣的结果。然而，迄今为止看到的结果是不一致的。文献报告了两种材料不同程度的生物相容性和选择性，但人们普遍认为它们都具有杀菌作用。这种广泛的报道活动可能是由于石墨烯类材料可以作用于细胞的许多机制，包括：诱导氧化应激;由于锋利的边缘破坏膜;提供吸附的杂质;大大改变基底的刚度和粗糙度。在这个项目中，我们将使用表面接枝聚合物刷链与吸附的石墨烯和氧化石墨烯制造新型纳米复合材料表面。我们将测试有关石墨烯和细胞相互作用的文献假设，目的是生产选择性抗菌涂层。

项目成果

Accessible and sustainable Cu(0)-mediated radical polymerisation for the functionalisation of surfaces

• DOI: 10.1039/d0py00516a
• 发表时间: 2020-06
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: Oliver Frank Uttley;Leonie Alice Brummitt;S. Worrall;S. Edmondson