WOMEN'S PRODROMAL AND ACUTE SYMPTOMS OF MYOCARDIAL INFAR

女性心肌梗塞的前驱症状和急性症状

• 批准号: 6393048
• 负责人: Jean C McSweeney
• 金额: $ 11.57万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393048
• 关键词: African American; Hispanic Americans; acute disease /disorder; cardiovascular disorder; caucasian American; clinical research; disease /disorder proneness /risk; female; human subject; myocardial infarction; racial /ethnic difference; sign /symptom; women's health

Despite decades of research, cardiovascular disease kills more than half a million women each year, a greater number than the subsequent 16 causes of death combined. After an acute myocardial infarction (MI), women have a 16% mortality rate compared with 11% for men. Therefore, further investigation of acute MI in women is essential. Research investigating delay in seeking treatment associated with MI consistently reports women delay seeking treatment because they do not recognize symptoms of MI since their symptoms differ from expectations. Since delay in seeking treatment is associated with less effective and fewer treatment options, longer hospitalizations, and higher mortality and morbidity rates, women's symptomatology must be delineated. There is a growing consensus among clinicians and researchers that women with MI experience different symptoms than men do. However, few studies have specifically focused on women's symptoms of MI and heart disease or addressed prodromal symptoms, those symptoms that come and go prior to and change after the MI. To fill this void in research on women with MI and heart disease, the objective of this proposal is to delineate prodromal and acute symptoms of MI. White, black, and Hispanic women will be targeted since they delay seeking treatment longer than other groups, are more likely to have cardiac risk factors, and have higher mortality rates after MI. The researchers will conduct a telephone survey of 1540 women from 8 medical centers. To ensure representation of ethnic minorities, quotas will be set at a minimum of 186 black and 171 Hispanic women. The women will be queried about their prodromal and acute symptoms of MI and cardiovascular risk status four to six months after their MI. This allows them time to identify prodromal symptoms of their MI. The data will be analyzed to compare prodromal and acute symptoms of white, black, and Hispanic women when contributing for cardiovascular risk status. Results of this study will help us to more fully describe prodromal and acute symptomatology in women with heart disease and MI.

尽管经过数十年的研究，心血管疾病每年仍导致超过 50 万女性死亡，这一数字比随后的 16 种死因的总和还多。急性心肌梗塞 (MI) 后，女性死亡率为 16%，而男性死亡率为 11%。因此，对女性急性心肌梗死的进一步调查至关重要。调查与 MI 相关的延迟寻求治疗的研究一致报告，女性延迟寻求治疗是因为她们的症状与预期不同，因此无法识别 MI 的症状。由于延迟寻求治疗与治疗效果较差、治疗选择较少、住院时间较长以及死亡率和发病率较高有关，因此必须描述女性的症状。临床医生和研究人员越来越一致地认为，患有心肌梗死的女性会经历与男性不同的症状。然而，很少有研究专门关注女性的心肌梗死和心脏病症状，或探讨前驱症状，即那些在心肌梗死之前出现和消失以及在心肌梗死之后发生变化的症状。为了填补对患有心肌梗死和心脏病的女性研究的这一空白，本提案的目的是描述心肌梗死的前驱症状和急性症状。白人、黑人和西班牙裔女性将成为目标，因为她们比其他群体延迟寻求治疗的时间更长，更有可能有心脏危险因素，并且心肌梗死后死亡率更高。研究人员将对来自8个医疗中心的1540名女性进行电话调查。为了确保少数族裔的代表性，配额将至少设定为 186 名黑人女性和 171 名西班牙裔女性。这些女性将在心肌梗死后四到六个月内被询问其心肌梗死的前驱症状和急性症状以及心血管风险状况。这让他们有时间识别心肌梗死的前驱症状。将分析这些数据，以比较白人、黑人和西班牙裔女性在心血管风险状态方面的前驱症状和急性症状。这项研究的结果将帮助我们更全面地描述患有心脏病和心肌梗死的女性的前驱症状和急性症状。