LX MULTI-NUCLEAR SPECTROSCOPY PACKAGE

LX 多核能谱套件

• 批准号: 6053099
• 负责人: RUSSELL S RICHARDSON
• 金额: $ 25.86万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053099
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging

In vivo 31P magnetic resonance spectroscopy has revolutionized the study of skeletal muscle metabolism and bioenergetics. Its non-invasive nature raises it above the traditional needle biopsy technique to repeatedly assess metabolic conditions within skeletal muscle in both healthy and diseased states. Analysis of the phosphorus spectra provide a wealth of information pertinent to the metabolic capacity and state of the muscle as indicated by variables such as phosphocreatine, inorganic phosphate, adenosine triphosphate concentrations and pH. In addition to the collection of this metabolic data by the use of small surface coils, the implementation of whole-volume multi-voxel localization or 31P spectroscopic imaging provides important spatial information about metabolism in a given tissue. Prior to early 1998 the skeletal muscle researchers submitting this application had access to these powerful tools at the VA medical center in La Jolla and as the publication records illustrate were very productive. However, recently the MRI was upgraded to a new General Electric (GE) magnet and the 31P spectroscopy capability was lost. Although several of these researchers have continued to work with 31P measurements at a location 150 miles from the UCSD campus, this is a temporary and clearly sub-optimal situation. Thus, the purpose of this grant application is to restore the 31P capability to the VA Hospital MRI in La Jolla by fiinding the purchase of the LX Multi- Nuclear Spectroscopy Package manufactured by GE. This would restore the previously available and productively utilized ability to non- invasively measure indices of muscle metabolism in both health and disease allowing the planned progression of the ongoing funded research.

在活体内，31P磁共振波谱已经彻底改变了骨骼肌代谢和生物能量学的研究。它的非侵入性使其超越了传统的针刺活检技术，可以在健康和疾病状态下反复评估骨骼肌内的代谢状况。对磷光谱的分析提供了与肌肉的代谢能力和状态相关的丰富信息，如磷酸肌酸、无机磷、三磷酸腺苷浓度和pH等变量所指示的。除了使用小表面线圈收集代谢数据外，全体积多体素定位或31P光谱成像的实施还提供了关于给定组织中新陈代谢的重要空间信息。在1998年初之前，提交这项申请的骨骼肌研究人员可以在拉霍亚的退伍军人医学中心使用这些强大的工具，正如出版记录所示，这些工具非常有成效。然而，最近MRI被升级为新的通用电气(GE)磁体，失去了31P光谱能力。尽管其中几名研究人员继续在距离加州大学圣迭戈分校150英里的地方进行31P测量，但这是暂时的，显然不是最理想的情况。因此，这项赠款申请的目的是通过现场定位购买GE制造的LX多核谱学组件，恢复位于拉霍亚的VA医院MRI的31P能力。这将恢复以前可用和有效利用的非侵入性测量健康和疾病肌肉新陈代谢指数的能力，从而使正在进行的资助研究能够按计划进行。