EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE

训练对供氧平衡的影响

• 批准号: 6349333
• 负责人: RUSSELL S RICHARDSON
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349333
• 关键词: bioimaging /biomedical imaging; biomedical resource; carbohydrates; epidemiology; magnetic resonance imaging; medical rehabilitation related tag; musculoskeletal system; nervous system; rehabilitation

Since their return from the Persian Gulf region, a large number of veterans have reported health problems. Among the most frequent complaints are fatigue, muscle pain, and muscle weakness. In an effort to investigate the etiology responsible for the ongoing chronic fatigue and muscle weakness, we are performing a comprehensive evaluation of skeletal muscle in PG veterans afflicted with chronic fatigue and muscular weakness and in a control group of healthy veterans. To date, 40 Persian Gulf Veterans have been studied 25 suffering from chronic fatigue and muscle weakness (age 33$3yrs; weight 181$11lbs) and 15 controls (age 28$2yrs; weight 180$6lbs). There was only an 8% difference in the rate of PCr resynthesis, a measure of in vivo oxidative capacity, between the veterans with muscular complaints and the healthy veterans. The PCr resynthesis rate constant was 2.19$0.10 s-1 (Mean$SEM) in the sick Persian Gulf veterans and 2.36$0.11 s-1 in the healthy control veterans. Additionally, MRI measurements of subjects from both populations revealed no difference in the cross-sectional area of the calf muscles. Resting spectra from both populations showed little difference. The Pi/PCr of the healthy veterans was 0.13$0.01 [mM] compared with 0.14$0.01 [mM] in sick veterans. In order to verify the subjective reports of muscle weakness and fatigue, we measured muscular strength and endurance in both populations. The right calf was monitored during isometric and isokinetic contractions. Isometric strength differed between the populations by 50%, with an average peak torque of 86.6$10.8 in the sick veterans and 128.7$11.3 in the healthy ve terans. The relative fatiguability, in contrast, was the same in both groups. However, the sick group performed half as much total absolute work during the same number of maximal contractions (412.1$74.6J versus 795.1$124.3J for the healthy group).Further examination of skeletal muscle using a combination of electrical stimulation, muscle biopsies and EMG will be performed to confirm the myopathic origin of chronic fatigue and muscle weakness in PG illness. In addition, DNA samples will be screened for genetic defects, or polymorphisms, which may have predisposed individuals to develop Persian Gulf illness.

自从他们从波斯湾地区返回以来，大批 退伍军人报告了健康问题。 其中最常见的 主诉是疲劳、肌肉疼痛和肌肉无力。 在一个 努力调查造成持续慢性疾病的病因 疲劳和肌肉无力，我们正在进行全面的检查 患有慢性病的 PG 退伍军人的骨骼肌评估 疲劳和肌肉无力以及健康对照组 退伍军人。 迄今为止，已对 40 名波斯湾退伍军人进行了研究 25 患有慢性疲劳和肌肉无力（年龄33$3岁； 体重 181 美元 11 磅）和 15 个对照（年龄 28 美元 2 岁；体重 180 美元 6 磅）。 PCr 再合成率仅存在 8% 的差异， 退伍军人之间体内氧化能力的测量 肌肉抱怨和健康的退伍军人。 PCR再合成 患病波斯湾的速率常数为 2.19$0.10 s-1 (Mean$SEM) 退伍军人和健康对照退伍军人中的 2.36$0.11 s-1。 此外，对两个人群的受试者进行 MRI 测量 显示小腿横截面积没有差异 肌肉。 两个种群的静息光谱几乎没有显示出 不同之处。 健康退伍军人的 Pi/PCr 为 0.13$0.01 [mM] 相比之下，患病退伍军人的感染率为 0.14$0.01 [mM]。 为了验证 我们测量了肌肉无力和疲劳的主观报告 两个人群的肌肉力量和耐力。 右小腿 在等长收缩和等速收缩期间进行监测。 等距 不同种群之间的强度差异为 50%，平均峰值 生病的退伍军人的扭矩为 86.6$10.8，健康的退伍军人的扭矩为 128.7$11.3 ve terans。 相比之下，相对疲劳度是相同的 两组。 然而，患病组的总成绩只有一半 相同次数的最大收缩期间的绝对功 （健康组为 412.1$74.6J 对比 795.1$124.3J）。进一步 结合电学检查骨骼肌 将进行刺激、肌肉活检和肌电图来确认 PG 病中慢性疲劳和肌无力的肌病起源。 此外，还将对 DNA 样本进行遗传缺陷筛查，或 多态性，这可能使个体倾向于发展 波斯湾疾病。