EFFECT OF AGE ON CONTROL OF SKELETAL MUSCLE BLOOD FLOW AND METABOLISM

年龄对骨骼肌血流和代谢控制的影响

• 批准号: 7374154
• 负责人: RUSSELL S RICHARDSON
• 金额: $ 2.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374154
• 关键词: aging; biopsy; birth; blood; capillary; metabolism; striated muscles; training

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine and compare the kinetics of blood flow and 02 delivery and utilization within young and old individuals. Determine change in 02 transport and utilization variables from beginning of training until the end achieved by young and old subjects. Determine minute blood flow response to a mild CO load and compare young and old subjects. Determine the metabolic reserve capacity when subjects are not centrally limited and compare young and old. Determine the metabolic reserve capacity when subjects are centrally limited and compare young and old. Determine the change in capillary and mitochrondrial formations before and after training in young and old subjects, determine the biochemical changes both via biopsy and MRS, and determine the angiogenic signaling processes that are active in young and old.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。确定并比较年轻和年长个体的血流动力学以及 02 输送和利用。确定年轻和年老受试者从训练开始到结束时 02 运输和利用变量的变化。确定对轻微二氧化碳负荷的分钟血流反应，并比较年轻和年长的受试者。确定受试者不受中央限制时的代谢储备能力并比较年轻人和老年人。确定受试者集中受限时的代谢储备能力并比较年轻人和老年人。确定年轻和老年受试者训练前后毛细血管和线粒体结构的变化，通过活检和 MRS 确定生化变化，并确定年轻人和老年人中活跃的血管生成信号过程。