EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE

训练对供氧平衡的影响

• 批准号: 6121070
• 负责人: RUSSELL S RICHARDSON
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121070
• 关键词: biomedical resource; female; human subject; male; musculoskeletal system; physical fitness

This study is part of a continuing collaboration with the University of California at San Diego, first established in 1993. The purpose of this study is determine the conditions under which oxygen delivery limits or impairs muscle performance. Previous studies demonstrated a sensitive balance between oxygen delivery and uptake in athletes, but concluded that this relationship was absent in untrained sedentary normals. These findings suggested that the oxygen delivery capacity of the capillary system far exceeded the ability of the muscle mitochondrial system to utilize oxygen in normal, undeveloped muscle, while in athletic muscle, the maximal performance of the muscle was limited by this same capillary system. However, it was not known whether this was due to natural variations in humans, or whether this was a developmental adaptation in trained muscle. To test this hypothesis, the untrained normals were put through a ten-week training session and retested. The results after training demonstrated a trend in sensitivity to blood oxygenation similar to the response of the athletes, suggesting that muscle normally has an abundant reserve of oxygen supply, but that muscle development results in a better match between oxygen delivery and utilization. This also suggests that all muscle possesses a natural limit to maximal performance which is ultimately determined by the capillary network.

这项研究是与 加州大学圣地亚哥分校，始建于1993年。这个 这项研究的目的是确定氧气在什么条件下 分娩限制或损害肌肉性能。以前的研究 表现出氧气输送和摄取之间的敏感平衡 运动员，但得出的结论是，这种关系在未经训练的人中是不存在的 久坐不动的正常人。这些发现表明，氧气的输送 毛细管系统的容量远远超过了 正常、未发育肌肉线粒体系统对氧的利用 肌肉，而在运动肌肉中， 肌肉也受到同样的毛细血管系统的限制。然而，事实并非如此 知道这是由于人类的自然变异，还是 这是经过训练的肌肉的发育适应。为了测试这一点 假设，未经训练的正常人接受了为期10周的训练 会话并重新测试。训练后的成绩呈现出一种趋势 在对血液氧合的敏感性上类似于 运动员，这表明肌肉通常有丰富的储备 氧气供应，但肌肉的发展会带来更好的匹配 氧气的输送和利用之间的关系。这也表明，所有的 肌肉拥有对最大表现的自然限制，即 最终由毛细血管网络决定。