EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE
训练对供氧平衡的影响
基本信息
- 批准号:6657667
- 负责人:
- 金额:$ 22.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-09-01 至 2003-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Since their return from the Persian Gulf region, a large number of
veterans have reported health problems. Among the most frequent
complaints are fatigue, muscle pain, and muscle weakness. In an
effort to investigate the etiology responsible for the ongoing chronic
fatigue and muscle weakness, we are performing a comprehensive
evaluation of skeletal muscle in PG veterans afflicted with chronic
fatigue and muscular weakness and in a control group of healthy
veterans. To date, 40 Persian Gulf Veterans have been studied 25
suffering from chronic fatigue and muscle weakness (age 33$3yrs;
weight 181$11lbs) and 15 controls (age 28$2yrs; weight 180$6lbs).
There was only an 8% difference in the rate of PCr resynthesis, a
measure of in vivo oxidative capacity, between the veterans with
muscular complaints and the healthy veterans. The PCr resynthesis
rate constant was 2.19$0.10 s-1 (Mean$SEM) in the sick Persian Gulf
veterans and 2.36$0.11 s-1 in the healthy control veterans.
Additionally, MRI measurements of subjects from both populations
revealed no difference in the cross-sectional area of the calf
muscles. Resting spectra from both populations showed little
difference. The Pi/PCr of the healthy veterans was 0.13$0.01 [mM]
compared with 0.14$0.01 [mM] in sick veterans. In order to verify the
subjective reports of muscle weakness and fatigue, we measured
muscular strength and endurance in both populations. The right calf
was monitored during isometric and isokinetic contractions. Isometric
strength differed between the populations by 50%, with an average peak
torque of 86.6$10.8 in the sick veterans and 128.7$11.3 in the healthy
ve terans. The relative fatiguability, in contrast, was the same in
both groups. However, the sick group performed half as much total
absolute work during the same number of maximal contractions
(412.1$74.6J versus 795.1$124.3J for the healthy group).Further
examination of skeletal muscle using a combination of electrical
stimulation, muscle biopsies and EMG will be performed to confirm the
myopathic origin of chronic fatigue and muscle weakness in PG illness.
In addition, DNA samples will be screened for genetic defects, or
polymorphisms, which may have predisposed individuals to develop
Persian Gulf illness.
自从他们从波斯湾地区返回以来,有大量的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RUSSELL S RICHARDSON其他文献
RUSSELL S RICHARDSON的其他文献
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{{ truncateString('RUSSELL S RICHARDSON', 18)}}的其他基金
EFFECT OF AGE ON CONTROL OF SKELETAL MUSCLE BLOOD FLOW AND METABOLISM
年龄对骨骼肌血流和代谢控制的影响
- 批准号:
7374154 - 财政年份:2006
- 资助金额:
$ 22.55万 - 项目类别:
Age Control of Skeletal Muscle Blood Flow and Metabolism
骨骼肌血流量和代谢的年龄控制
- 批准号:
7045413 - 财政年份:2003
- 资助金额:
$ 22.55万 - 项目类别:
EFFECT OF AGE ON CONTROL OF SKELETAL MUSCLE BLOOD FLOW AND METABOLISM
年龄对骨骼肌血流和代谢控制的影响
- 批准号:
7205590 - 财政年份:2003
- 资助金额:
$ 22.55万 - 项目类别:
Oxygen transport and utilization: Effects of age
氧气输送和利用:年龄的影响
- 批准号:
6589832 - 财政年份:2002
- 资助金额:
$ 22.55万 - 项目类别:
EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE
训练对供氧平衡的影响
- 批准号:
6495476 - 财政年份:2001
- 资助金额:
$ 22.55万 - 项目类别:
Oxygen transport and utilization: Effects of age
氧气输送和利用:年龄的影响
- 批准号:
6452646 - 财政年份:2001
- 资助金额:
$ 22.55万 - 项目类别:
EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE
训练对供氧平衡的影响
- 批准号:
6349333 - 财政年份:2000
- 资助金额:
$ 22.55万 - 项目类别:
EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE
训练对供氧平衡的影响
- 批准号:
6121070 - 财政年份:1998
- 资助金额:
$ 22.55万 - 项目类别:
EFFECTS OF ALTERED OXYGEN DELIVERY ON MUSCLE METABOLISM
改变供氧量对肌肉代谢的影响
- 批准号:
6252183 - 财政年份:1997
- 资助金额:
$ 22.55万 - 项目类别:
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