EFFECTS OF TRAINING ON BALANCE BETWEEN OXYGEN DELIVERY & UTILIZATION IN MUSCLE

训练对供氧平衡的影响

• 批准号: 6657667
• 负责人: RUSSELL S RICHARDSON
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657667
• 关键词: bioimaging /biomedical imaging; biomedical resource; carbohydrates; epidemiology; magnetic resonance imaging; medical rehabilitation related tag; musculoskeletal system; nervous system; rehabilitation

Since their return from the Persian Gulf region, a large number of veterans have reported health problems. Among the most frequent complaints are fatigue, muscle pain, and muscle weakness. In an effort to investigate the etiology responsible for the ongoing chronic fatigue and muscle weakness, we are performing a comprehensive evaluation of skeletal muscle in PG veterans afflicted with chronic fatigue and muscular weakness and in a control group of healthy veterans. To date, 40 Persian Gulf Veterans have been studied 25 suffering from chronic fatigue and muscle weakness (age 33$3yrs; weight 181$11lbs) and 15 controls (age 28$2yrs; weight 180$6lbs). There was only an 8% difference in the rate of PCr resynthesis, a measure of in vivo oxidative capacity, between the veterans with muscular complaints and the healthy veterans. The PCr resynthesis rate constant was 2.19$0.10 s-1 (Mean$SEM) in the sick Persian Gulf veterans and 2.36$0.11 s-1 in the healthy control veterans. Additionally, MRI measurements of subjects from both populations revealed no difference in the cross-sectional area of the calf muscles. Resting spectra from both populations showed little difference. The Pi/PCr of the healthy veterans was 0.13$0.01 [mM] compared with 0.14$0.01 [mM] in sick veterans. In order to verify the subjective reports of muscle weakness and fatigue, we measured muscular strength and endurance in both populations. The right calf was monitored during isometric and isokinetic contractions. Isometric strength differed between the populations by 50%, with an average peak torque of 86.6$10.8 in the sick veterans and 128.7$11.3 in the healthy ve terans. The relative fatiguability, in contrast, was the same in both groups. However, the sick group performed half as much total absolute work during the same number of maximal contractions (412.1$74.6J versus 795.1$124.3J for the healthy group).Further examination of skeletal muscle using a combination of electrical stimulation, muscle biopsies and EMG will be performed to confirm the myopathic origin of chronic fatigue and muscle weakness in PG illness. In addition, DNA samples will be screened for genetic defects, or polymorphisms, which may have predisposed individuals to develop Persian Gulf illness.

自从他们从波斯湾地区返回以来， 退伍军人报告了健康问题。 的最常见 主诉是疲劳、肌肉疼痛和肌肉无力。 中 努力调查病因负责正在进行的慢性 疲劳和肌肉无力，我们正在进行全面的 评估PG退伍军人患有慢性 疲劳和肌肉无力，并在对照组的健康 老兵 迄今为止，已对40名波斯湾退伍军人进行了研究25 患有慢性疲劳和肌肉无力（年龄33岁至3岁; 体重181 ± 11磅）和15名对照组（年龄28 ± 2岁;体重180 ± 6磅）。 PCR再合成率仅为8%， 体内氧化能力的测量，退伍军人与 肌肉不适和健康的退伍军人 PCR再合成 在患病的波斯湾，速率常数为2.19 ± 0.10 s-1（平均值为SEM 健康对照组为2.36$0.11s-1。 此外，两个人群受试者的MRI测量结果 显示小腿的横截面积没有差异 肌肉. 两个种群的静息光谱显示 差 健康退伍军人的Pi/PCr为0.13 ± 0.01 [mM] 而患病退伍军人为0.14 ± 0.01 [mM]。 为了验证 肌肉无力和疲劳的主观报告，我们测量了 肌肉力量和耐力。 右小腿 在等长和等速收缩期间监测。 等距 种群之间的强度差异为50%，平均峰值为 患病退伍军人的扭矩为86.6$10.8，健康退伍军人的扭矩为128.7$11.3 我也是。 相比之下， 两组。 然而，生病的那一组的表现只有总成绩的一半， 最大收缩次数相同时的绝对功 （412.1 $74.6J与健康组的795.1 $124.3J）。 骨骼肌的检查，使用组合的电 将进行刺激、肌肉活检和EMG，以确认 PG疾病中慢性疲劳和肌无力的肌病起源。 此外，将对DNA样本进行遗传缺陷筛查，或 多态性，这可能使个体易于发展 波斯湾疾病。