RISK OF OSTEOPOROSIS IN PATIENTS WITH RECENT ONSET SYSTEMIC LUPUS ERYTHMATOSUS

SLE是一种慢性、炎症性、自身免疫性疾病，其特征在于恶化和缓解。 最不可预测的病程最有可能发生在疾病的最初几年。 初步证据表明，狼疮妇女的低骨密度频率增加。 狼疮患者骨密度低的原因尚不清楚。 我们将研究以下假设：在疾病发作的前两年，骨丢失加速，并且这种骨丢失与狼疮疾病及其治疗（狼疮疾病活动，炎症介质水平和/或类固醇负荷）有关。这是一项对30例病程少于2年的狼疮患者进行的先导性纵向研究。 具体目标是：1）在基线和随访一年后测量骨矿物质密度（BMD），2）估计一年内骨矿物质密度的变化率，3）分析一年内每三个月测量一次的狼疮疾病活动、炎症介质和类固醇负荷与BMD和BMD变化的关系，以及4）探索狼疮疾病活动、炎症介质和类固醇负荷与BMD和BMD变化的关系。炎症介质和类固醇负荷，在一年的过程中每三个月测量一次，用骨形成和骨吸收的生化标志物。

SLE is a chronic, inflammatory, autoimmune disease characterized by exacerbations and remissions. The most unpredictable disease course is most likely to occur during the first few years of the illness. Preliminary evidence has documented an increased frequency of low bone mineral density in women with lupus. The reasons for low BMD in lupus patients are unclear. We will investigate the hypotheses that bone loss is accelerated during the first two years of disease onset and that this loss of bone is related to lupus disease and its treatment (lupus disease activity, levels of inflammatory mediators, and/or steroid burden). This is a pilot, longitudinal study of 30 patients with lupus of less than 2 years duration. The specific aims are: 1) to measure bone mineral density (BMD) at baseline and after one year of follow up, 2) to estimate the rate of change in bone mineral density over one year, 3) to analyze the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with BMD and change in BMD, and 4) to explore the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with biochemical markers of bone formation and bone resorption.