BRAIN: IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING

大脑:17O 的体内测量,带表面盘管蒸汽去耦

基本信息

  • 批准号:
    6495443
  • 负责人:
  • 金额:
    $ 22.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-01 至 2002-08-31
  • 项目状态:
    已结题

项目摘要

Osteoarthritis is a degenerative disease of cartilage, affecting 40 million Americans and more than 80% of people age 55 and over. It is characterized by degradation of the cartilage matrix with symptoms of joint stiffness and swelling, bony enlargements, and pain. Cartilage consists mainly of an extra-cellular matrix (ECM) of type II collagen and proteoglycans, in an intertwining array. Water content in cartilage ranges from 70% to 80%. Approximately 60% of the dry weight of cartilage is collagen, with the remainder mostly being the proteoglycans (PG). It is now known that degradation of cartilage in an early osteoarthritic condition primarily involves the loss of the PG. We have imaged a healthy human knee using saline/agarose phantoms whose 23Na relaxation times have been normalized to cartilage. This allows the creation of a calibration curve to fit pixel intensities of the cartilage to in an effort to quantitate the signal. This sodium signal directly corresponds to the PG content in the cartilage, thereby providing a method to monitor tissue integrity. We are investigating the use of surface coils, a birdcage coil and a transmit only birdcage coil with surface receive coils. We are currently underway in a plan to determine sodium concentrations in several healthy human volunteers as well as subjects grouped by age.
骨关节炎是一种软骨退行性疾病,影响

项目成果

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SRIDHAR R CHARAGUNDLA其他文献

SRIDHAR R CHARAGUNDLA的其他文献

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{{ truncateString('SRIDHAR R CHARAGUNDLA', 18)}}的其他基金

MEASUREMENT OF VENTRICULAR DYSSYNCHRONY WITH CARDIAC MRI
用心脏 MRI 测量心室不同步
  • 批准号:
    7600822
  • 财政年份:
    2007
  • 资助金额:
    $ 22.55万
  • 项目类别:
NEW PULSE SEQUENCE FOR INDIRECT DETECTION OF 17O IN BRAIN
用于间接检测大脑中 17O 的新脉冲序列
  • 批准号:
    6657633
  • 财政年份:
    2002
  • 资助金额:
    $ 22.55万
  • 项目类别:
BRAIN: IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING
大脑:17O 的体内测量,带表面盘管蒸汽去耦
  • 批准号:
    6657634
  • 财政年份:
    2002
  • 资助金额:
    $ 22.55万
  • 项目类别:
BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO
BRAIN:T1_ 17O 体内色散成像
  • 批准号:
    6657635
  • 财政年份:
    2002
  • 资助金额:
    $ 22.55万
  • 项目类别:
BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO
BRAIN:T1_ 17O 体内色散成像
  • 批准号:
    6495444
  • 财政年份:
    2001
  • 资助金额:
    $ 22.55万
  • 项目类别:
NEW PULSE SEQUENCE FOR INDIRECT DETECTION OF 17O IN BRAIN
用于间接检测大脑中 17O 的新脉冲序列
  • 批准号:
    6495442
  • 财政年份:
    2001
  • 资助金额:
    $ 22.55万
  • 项目类别:
NEW PULSE SEQUENCE FOR INDIRECT DETECTION OF 17O IN BRAIN
用于间接检测大脑中 17O 的新脉冲序列
  • 批准号:
    6349299
  • 财政年份:
    2000
  • 资助金额:
    $ 22.55万
  • 项目类别:
BRAIN: IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING
大脑:17O 的体内测量,带表面盘管蒸汽去耦
  • 批准号:
    6349300
  • 财政年份:
    2000
  • 资助金额:
    $ 22.55万
  • 项目类别:
BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO
BRAIN:T1_ 17O 体内色散成像
  • 批准号:
    6349301
  • 财政年份:
    2000
  • 资助金额:
    $ 22.55万
  • 项目类别:
IN VIVO MEASUREMENT OF 17O W/ SURFACE COIL STEAM DECOUPLING
带表面盘管蒸汽去耦的 17O 体内测量
  • 批准号:
    6121032
  • 财政年份:
    1998
  • 资助金额:
    $ 22.55万
  • 项目类别:

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Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
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