BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO

BRAIN:T1_ 17O 体内色散成像

• 批准号: 6495444
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495444
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

We are developing a novel technique for indirect 17O detection by combining 1H spin-locking and 17O decoupling into an interleaved spin-locking/decoupling sequence. This sequence appears to reproduce simultaneous irradiation of the nuclei, while using a single, double-tuned coil. Preliminary experiments indicate an improvement in signal-to-noise ratios of proton spectra (as compared to 17O-decoupled 1H spectra) and a correspondingly greater accuracy in the detection of 17O. This sequence suggests itself for use as a preparatory pulse cluster in fast imaging sequences and may even prove useful in the transfer of heteronuclear polarization in scalar-coupled systems modulated by chemical exchange. We have continued work on characterization of this sequence; in particular, we are empirically investigating optimal pulse timing parameters and theoretically modelling the sequence. Furthermore, we are studying the sensitivity and specificity of the sequence to the presence of 17 O by measuring the effects of gadolinium-doping on proton signal enhancement.

我们正在开发一种间接检测 17O 的新技术 将 1H 自旋锁定和 17O 解耦结合成交错 自旋锁定/解耦序列。 这个序列似乎重现了 同时照射原子核，同时使用单个， 双调谐线圈。 初步实验表明，在 质子光谱的信噪比（与 17O 解耦相比） 1H 光谱）以及相应更高的检测精度 17O。 该序列建议用作预备脉冲 聚类在快速成像序列中，甚至可能在 标量耦合系统中异核极化的转移 通过化学交换调节。 我们继续致力于 该序列的表征；特别是，我们凭经验 研究最佳脉冲定时参数并从理论上进行 对序列进行建模。 此外，我们正在研究敏感性 以及通过测量序列对 17 O 存在的特异性 钆掺杂对质子信号增强的影响。