MEASUREMENT OF VENTRICULAR DYSSYNCHRONY WITH CARDIAC MRI

用心脏 MRI 测量心室不同步

• 批准号: 7600822
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 1.65万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600822
• 关键词: Acceleration; Blur; Cardiac; Compatible; Computer Retrieval of Information on Scientific Projects Database; Detection; Development; Funding; Grant; Heart failure; Imaging Techniques; Institution; Magnetic Resonance Imaging; Measurement; Methods; Motion; Physiological; Radial; Research; Research Personnel; Resources; Sampling; Simulate; Source; Symptoms; United States National Institutes of Health; Ventricular; design; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ventricular dyssynchrony is an important contributing factor in the development of heart failure symptoms, however detection of this entity is suboptimal with existing imaging techniques. We seek to develop improved methods of detecting and quantifying dyssynchrony using tagged cardiac MRI. To this end, we have designed an MR-compatible motion phantom that simulates physiologic cardiac displacements, velocities, and acceleration. Preliminary results suggest that radial k-space sampling is less sensitive to motion blurring and benefits from viewsharing to a greater extent.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心室不同步是心力衰竭症状发展的一个重要因素，然而，现有成像技术对该实体的检测并不理想。 我们寻求开发使用标记心脏MRI检测和量化不同步的改进方法。 为此，我们设计了一个MR兼容的运动体模，模拟生理心脏位移，速度和加速度。 初步结果表明，径向k空间采样对运动模糊不太敏感，并且在更大程度上受益于视图共享。