BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO

BRAIN:T1_ 17O 体内色散成像

• 批准号: 6349301
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 2.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349301
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

We are developing a novel technique for indirect 17O detection by combining 1H spin-locking and 17O decoupling into an interleaved spin-locking/decoupling sequence. This sequence appears to reproduce simultaneous irradiation of the nuclei, while using a single, double-tuned coil. Preliminary experiments indicate an improvement in signal-to-noise ratios of proton spectra (as compared to 17O-decoupled 1H spectra) and a correspondingly greater accuracy in the detection of 17O. This sequence suggests itself for use as a preparatory pulse cluster in fast imaging sequences and may even prove useful in the transfer of heteronuclear polarization in scalar-coupled systems modulated by chemical exchange. We have continued work on characterization of this sequence; in particular, we are empirically investigating optimal pulse timing parameters and theoretically modelling the sequence. Furthermore, we are studying the sensitivity and specificity of the sequence to the presence of 17 O by measuring the effects of gadolinium-doping on proton signal enhancement.

我们正在开发一种新的间接17 O检测技术， 将1H自旋锁定和17 O去耦组合成交错的 自旋锁定/去耦序列。 这个序列似乎复制了 核的同时照射，同时使用单个， 双调谐线圈 初步实验表明， 质子光谱的信噪比（与17 O-去耦相比 1H光谱）和相应更高的检测精度 17O 这一序列表明它本身可用作预备脉冲 集群在快速成像序列，甚至可以证明有用的， 标量耦合系统中的异向极化传递 通过化学交换调节。 我们继续致力于 这一序列的特征;特别是，我们是经验 研究最佳脉冲定时参数， 模拟序列。 此外，我们还在研究 和特异性的序列的存在17 O通过测量 钆掺杂对质子信号增强的影响。