T1R DISPERSION IMAGING OF 17O OPTIMIZATION W/ ERROR ANALYSIS

质子T1r色散成像作为一种方法具有很大的前景， 测量和成像17O浓度。 然而，谨慎选择 脉冲序列参数对其正确操作至关重要。 在 特别是自旋锁定时间和自旋锁定功率的选择 在最大限度地提高灵敏度和特异性方面至关重要 17O。 我们已经开始使用“误差传播”分析， 确定组织的最佳自旋锁定功率和时间， 不同的弛豫特性和17O浓度。 的结果 我们的数学模型将在体外和体内进行验证 实验

Proton T1r dispersion imaging holds great promise as a method of measuring and imaging 17O concentrations. However, careful choice of pulse sequence parameters is crucial to its proper operation. In particular, the choices of spin-locking times and spin-locking powers are of utmost importance in maximizing the sensitivity and specificity for 17O. We have begun to use a "propagation of error" analysis to determine the optimum spin-locking powers and times for tissues of varying relaxation properties and 17O concentrations. The results of our mathematical modelling will be verified with in vitro and in vivo experiments.