BRAIN:T1_ DISPERSION IMAGING OF 17O IN VIVO

BRAIN:T1_ 17O 体内色散成像

• 批准号: 6657635
• 负责人: SRIDHAR R CHARAGUNDLA
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657635
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

We are developing a novel technique for indirect 17O detection by combining 1H spin-locking and 17O decoupling into an interleaved spin-locking/decoupling sequence. This sequence appears to reproduce simultaneous irradiation of the nuclei, while using a single, double-tuned coil. Preliminary experiments indicate an improvement in signal-to-noise ratios of proton spectra (as compared to 17O-decoupled 1H spectra) and a correspondingly greater accuracy in the detection of 17O. This sequence suggests itself for use as a preparatory pulse cluster in fast imaging sequences and may even prove useful in the transfer of heteronuclear polarization in scalar-coupled systems modulated by chemical exchange. We have continued work on characterization of this sequence; in particular, we are empirically investigating optimal pulse timing parameters and theoretically modelling the sequence. Furthermore, we are studying the sensitivity and specificity of the sequence to the presence of 17 O by measuring the effects of gadolinium-doping on proton signal enhancement.

我们正在开发一种通过以下方式间接检测17O的新技术 将1H自旋锁定和17O去耦合组合成交错 自旋锁定/解耦序列。这一序列似乎复制了 同时照射原子核，同时使用单一的， 双调线圈。初步实验表明， 质子光谱的信噪比(与170度去耦合相比 1H谱)和相应更高的检测精度 17O。该序列建议将其用作预备脉冲 快速成像序列中的簇，甚至可能被证明在 标量耦合系统中的异核极化转移 由化学交换调节的。我们还在继续研究 这一序列的特征；特别是，我们在经验上 最优脉冲定时参数研究及理论分析 对序列进行建模。此外，我们正在研究敏感度 通过测量该序列对17O的存在的特异性 Gd掺杂对质子信号增强的影响。