Limbic Modulation of Arousal and Alerting

边缘系统对唤醒和警觉的调节

• 批准号: 6528979
• 负责人: LARRY D SANFORD
• 金额: $ 23.61万
• 依托单位: EASTERN VIRGINIA MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528979
• 关键词: REM sleep; amygdala; arousal; attention; behavioral /social science research tag; behavioral habituation /sensitization; brain electrical activity; cues; electroencephalography; electrostimulus; emotions; environmental stressor; fear; laboratory rat; locus coeruleus; microinjections; muscimol; posttraumatic stress disorder; psychological stressor; shock; sleep disorders; sleep regulatory center; stimulus /response; thalamus; wakefulness

DESCRIPTION (provided by applicant): The long-term goal of this project is to further our understanding of how emotional factors influence sleep and responsiveness to environmental stimuli. Emotional state has a major influence on how we react to the situations and events we experience, and it also has a strong influence on sleep quality and amount. This statement is both intuitive and factually supported by the observed role of emotional factors in human clinical sleep medicine and in psychiatric disorders in which sleep is affected. However the role of emotion virtually has been ignored in basic sleep research, possibly because of the lack of a clear anatomical focus, or perhaps because of a lack of established models. The amygdala, the limbic "center" of emotion, may be a key region for modulating the influence of emotion on sleep. There is a well-developed body of knowledge on the role of various amygdaloid nuclei in emotion, and emerging evidence indicating that the amygdala is a strong modulator of arousal state. We plan to selectively inactivate specific regions of the amygdala and brainstem to: 1) examine the role of amygdaloid input and output nuclei in modulating sleep and spontaneously generated neural markers of alerting. 2) examine the role of amygdaloid input and output nuclei in regulating sleep in response to fearful cues and contexts. 3) examine the role of these nuclei in modulating brain mechanisms of alerting in response to fearful cues and contexts. 4) examine the possibility that the effects of fearful cues and contexts on sleep and alerting are mediated through the locus coeruleus at the brainstem level. These studies will help elucidate how emotion, stress and the environment interact to influence sleep and responding to specific and non-specific stimuli in the environment, and they will determine the neural structures involved. These studies may provide critical insight into the development of sleep disorders which have an emotional element, such as insomnia and mental disorders in which sleep is affected. This work also may be especially relevant to posttraumatic stress disorder (PTSD), which is typically characterized by a prominent sleep disturbance in the aftermath of exposure to a psychologically traumatic stressor.

描述（由申请人提供）：该项目的长期目标是 进一步加深我们对情绪因素如何影响睡眠的理解 对环境刺激的反应能力。情绪状态有很大影响 关于我们如何对所经历的情况和事件做出反应，它还有一个 对睡眠质量和睡眠时间影响很大。这句话既直观又直观 并得到观察到的情绪因素在人类中的作用的事实支持 临床睡眠医学和睡眠障碍的精神疾病 做作的。然而，情绪在基本睡眠中的作用实际上被忽视了 研究，可能是因为缺乏明确的解剖焦点，或者可能是 因为缺乏既定的模型。杏仁核，边缘系统的“中心” 情绪可能是调节情绪对睡眠影响的关键区域。 关于各种杏仁核的作用有一个完善的知识体系 情绪的核，以及新出现的证据表明杏仁核是一个 唤醒状态的强调制器。我们计划选择性地停用特定的 杏仁核和脑干区域：1) 检查杏仁核的作用 调节睡眠和自发生成神经的输入和输出核 警报标记。 2）检查杏仁核输入和输出核的作用 调节睡眠以应对可怕的暗示和环境。 3）检查 这些核在调节大脑警报机制中的作用 可怕的暗示和背景。 4）检查影响的可能性 关于睡眠和警觉的恐惧线索和背景是通过基因座介导的 蓝核位于脑干水平。这些研究将有助于阐明如何 情绪、压力和环境相互作用影响睡眠和反应 对环境中的特定和非特定刺激，他们会 确定所涉及的神经结构。这些研究可能提供关键的 深入了解与情绪有关的睡眠障碍的发展 因素，例如失眠和影响睡眠的精神障碍。这 工作也可能与创伤后应激障碍（PTSD）特别相关， 其典型特征是显着的睡眠障碍 暴露于心理创伤性压力源后的后果。