Effect of aging and mitochondrial dysfunction on the optic nerve response to pressure-induced oxidative stress

衰老和线粒体功能障碍对视神经对压力诱导的氧化应激反应的影响

• 批准号: nhmrc : 475603
• 负责人: A/Pr Bang Bui
• 金额: $ 27.71万
• 依托单位: Centre for Eye Research Australia Ltd
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-aging-mitochondrial-oxidative-stress/98558
• 关键词: Effect; aging; mitochondrial; dysfunction; optic

The risk of glaucoma, a potentially blinding disease of the optic nerve, increases exponentially with age, but the cellular mechanisms responsible are not known. We hypothesise that age-related changes in mitochondria, the energy producing part of the cell, render nerve cells prone to damage. This project will determine whether aging and mitochondrial impairment increase nerve damage and whether dietary moodifications that preserve mitochondria during aging, protect the optic nerve from damage

青光眼是一种可能致盲的视神经疾病，其风险随着年龄的增长呈指数级增加，但其细胞机制尚不清楚。我们假设线粒体（细胞的能量产生部分）与年龄相关的变化使神经细胞容易受损。该项目将确定衰老和线粒体损伤是否会增加神经损伤，以及在衰老过程中保护线粒体的饮食调节是否可以保护视神经免受损伤