Understanding the genetic determinants of central corneal thickness and its functional role in glaucoma pathophysiology

了解中央角膜厚度的遗传决定因素及其在青光眼病理生理学中的功能作用

• 批准号: nhmrc : 535077
• 负责人: A/Pr Bang Bui
• 金额: $ 19.82万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-genetic-determinants-glaucoma-pathophysiology/95527
• 关键词: Understanding; genetic; determinants; central; corneal

Glaucoma is a common cause of blindness and visual diability in Australia. It is caused by a combination of environmental and genetic factors. People with a thin cornea (the clear covering at the front of the eye) are at increased risk of glaucoma. We are investigating the biological link between the cornea and glaucoma as well as identifying genes that determine corneal thickness. Some of these genes may also cause glaucoma. Understanding this will lead to better diagnosis and treatment.

青光眼是一种常见的致盲和视力障碍在澳大利亚。它是由环境和遗传因素共同造成的。角膜薄的人（眼睛前部的透明覆盖物）患青光眼的风险增加。我们正在研究角膜和青光眼之间的生物学联系，以及确定决定角膜厚度的基因。其中一些基因也可能导致青光眼。了解这一点将有助于更好的诊断和治疗。