Mechanisms of ganglion cell injury in glaucoma

青光眼神经节细胞损伤的机制

• 批准号: nhmrc : 400127
• 负责人: A/Pr Bang Bui
• 金额: $ 19.97万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-ganglion-cell-injury-glaucoma/95608
• 关键词: Mechanisms; ganglion; cell; injury; glaucoma

The aim of this project is to improve our understanding of the role that increased eye pressure (intraocular pressure or IOP) plays in the development of glaucoma-related nerve death and associated vision loss. Despite being the second leading cause of vision loss in Australia, our understanding of the factors that damage nerves in the eye (the ganglion cells that carry visual information to the brain) in glaucoma remains incomplete. For example, elevated eye pressure is a well-established risk factor for glaucoma, but as many as half of those with glaucoma do not have high eye pressure. Clinical data suggests that pressure fluctuations (or spikes), which go unnoticed in routine clinical check ups, may be involved in glaucoma onset and progression. To date there has been no direct evidence to support this contention. This project aims to use a novel experimental model of pressure elevation in rodents to consider this possibility. By measuring the eye's electrical response to a flash of light it is possible to sensitively assess how pressure spikes, that are known to occur with regularity in humans, might affect the health of retinal ganglion cells. Anatomical measures will also be used to establish the sequence of events that cause cellular damage. This knowledge is an important public health issue, because it will improve understanding of the risk factors for the development of glaucoma. The results may lead to improvements in detection and treatment strategies such as closer monitoring for pressure spikes and more aggressive treatment for those who show greater variability in their eye pressures.

该项目的目的是提高我们对眼压升高（眼内压或IOP）在青光眼相关神经死亡和相关视力丧失发展中的作用的理解。尽管青光眼是澳大利亚视力丧失的第二大原因，但我们对青光眼损伤眼睛神经（向大脑传递视觉信息的神经节细胞）的因素的了解仍然不完整。例如，眼压升高是青光眼的一个公认的危险因素，但多达一半的青光眼患者并没有眼压高。临床资料表明，在常规临床检查中未被注意到的压力波动（或尖峰）可能与青光眼的发生和发展有关。到目前为止，还没有直接证据支持这一论点。本项目旨在使用一种新的啮齿动物压力升高实验模型来考虑这种可能性。通过测量眼睛对闪光的电反应，有可能敏感地评估压力峰值是如何影响视网膜神经节细胞的健康的，这种压力峰值已知在人类中有规律地发生。解剖方法也将用于确定引起细胞损伤的事件序列。这是一个重要的公共卫生问题，因为它将提高对青光眼发展危险因素的认识。研究结果可能会改善检测和治疗策略，比如更密切地监测眼压峰值，对那些眼压变化较大的人进行更积极的治疗。