DEVELOPMENT OF COGNITIVE ACTIVATION TASKS FOR FUNCTIONAL NEUROIMAGING

我们已经开发了各种任务来激活功能神经成像研究中的感兴趣区域。1.我们开发了用于事件相关fMRI的注意和编码的连续操作测验。虽然精神分裂症患者的行为缺陷已被广泛报道，但这项任务的神经基础尚未阐明。为此，我们降级了刺激，只使用字母x和y，因此事件相关范例中的每个单独试验都是有信息的。2.我们开发了一套精心匹配的词汇流畅性任务，使用PET CBF方法考察了精神分裂症患者的语义加工、思维障碍和神经生理学之间的关系。我们还使用fMRI中的语义加工任务来确定重复启动和概念启动的生理伴随，以确定语义提取是否是自动的，以及这两个任务是否涉及相似的功能神经解剖学。3.为了考察情景记忆的加工水平，我们设计了一系列或再认记忆任务。我们还特别注意了不涉及主动加工的控制任务的发展，以便更好地观察海马区的激活。初步结果表明，在更高水平的编码过程中，有明显的前额叶皮层激活。

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. We developed a Continuous Performance Test of attention and encoding to be used in event related fMRI. While behavioral deficits have been widely reported in schizophrenic patients, the neural substrate of this task has yet to be elucidated. Toward this end we degraded stimuli and used only the letters x and y so each individual trial in an event related paradigm was informative. 2. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We arel also using a semantic processing task in fMRI to determine the physiologic concomitants of repetition priming versus conceptual priming in order to ascertain whether semantic access is automatic and if the two tasks involve similar functional neuroanatomies. 3. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. Preliminary results indicate marked prefrontal cortecal activations during higher level encoding.