NONINJECTING HEROIN USERS, NEW INJECTORS AND HIV RISK

非注射海洛因使用者、新注射器和艾滋病毒风险

• 批准号: 6378628
• 负责人: ALAN NEAIGUS
• 金额: $ 63.78万
• 依托单位: NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6378628
• 关键词: HIV infections; behavior prediction; behavioral /social science research tag; clinical research; disease /disorder proneness /risk; enzyme linked immunosorbent assay; hepatitis B; hepatitis C; heroin; high risk behavior /lifestyle; human subject; interview; intravenous drug abuse; longitudinal human study; peer group; serotyping; sex behavior; social integration; social support network; substance abuse epidemiology; substance abuse related behavior; urinalysis

Non-injecting heroin use is widespread in New York City and in many other cities. Non-injecting heroin users (NIUs) are at high risk of becoming injecting drug users (IDUs). Increases in the number of new IDUs can lead to many new infections with HIV, hepatitis B (HBV) and hepatitis C (HCV). This study will continue the "HIV Risk and Transitions from Non- Injecting Heroin Use" (NIU) cohort study of approximately 600 NIUs. It will follow the NIU cohort and a cohort of new IDUs, to determine: (1) the incidence and time-trends in transitions to injecting; (2) behavioral and network risks for transitions to injecting and other drug use outcomes; (3) separately, for new IDUs and for NIUs, the incidence and time-trends in HIV, HBV and HCV seroconversions; (4) among NIUs, sexual and other non- injecting risk behaviors and networks predicting HIV, HBV and HCV seroconversion; (5) among new IDUs, drug injecting and sexual risk behaviors and risk networks predicting HIV, HBV and HCV seroconversion; (6) time-trends in the prevalence of drug and sexual risk behaviors and risk networks, and factors predicting these trends; and (7) the impact of changes in the quality and availability of heroin, and in other community factors, on modes of drug administration and other drug and sexual risk behaviors and risk networks. The sample will include: NIUs from the parent study; new IDUs recruited from a supplemental study of network risks for HIV, HBV and HCV infection; and NIUs and new IDUs recruited during the study continuation. Participants will be interviewed and tested for HIV, HBV, and HCV. Ethnography will be used to study the impact of drug markets. Analyses of risk factors for transitions to injecting and seroconversions will explore the "network facilitation" hypothesis by examining the extent to which network characteristics, in interaction with risk behaviors, facilitate transitions to injecting or the cessation of heroin use and other drug use outcomes, and seroconversions. This approach will advance our knowledge of the interaction between network processes and risk behaviors, and can be used to develop interventions to change both risk behaviors and risk networks, and to prevent transitions to injecting and the risk of HIV, HBV and HCV infection.

非注射使用海洛因在纽约市和其他许多城市很普遍。 非注射海洛因使用者成为注射毒品使用者的风险很高。 新注射吸毒者人数的增加可导致许多新的艾滋病毒、B型肝炎和丙型肝炎感染。这项研究将继续进行“艾滋病毒风险和从非注射海洛因使用的过渡”（NIU）队列研究，约有600名NIU。 它将跟踪NIU队列和新注射吸毒者队列，以确定：（1）过渡到注射的发生率和时间趋势;（2）过渡到注射的行为和网络风险及其他药物使用结果;（3）分别针对新注射吸毒者和NIU，艾滋病毒、乙型肝炎病毒和丙型肝炎病毒血清转化的发生率和时间趋势;（4）在NIU中，性和其他非注射危险行为及网络预测HIV、HBV和HCV血清转换：（5）在新的IDUs中，注射毒品和性危险行为及网络预测HIV、HBV和HCV血清转换;（6）毒品和性风险行为及风险网络流行的时间趋势，以及预测这些趋势的因素;（7）海洛因质量和供应的变化以及其他社区因素对药物管理模式和其他毒品和性风险行为及风险网络的影响。样本将包括：来自母研究的NIU;从HIV、HBV和HCV感染网络风险的补充研究中招募的新注射吸毒者;以及在研究继续期间招募的NIU和新注射吸毒者。 参与者将接受采访和测试艾滋病毒，HBV和HCV。 人种学将用于研究毒品市场的影响。对过渡到注射和血清转化的风险因素的分析将探讨“网络促进”假说，方法是考察网络特征与风险行为相互作用在多大程度上促进过渡到注射或停止使用海洛因和其他药物使用结果以及血清转化。 这种方法将推进我们的网络过程和风险行为之间的相互作用的知识，并可用于制定干预措施，以改变风险行为和风险网络，并防止过渡到注射和艾滋病毒，HBV和HCV感染的风险。