Effect of pregnancy and pre-eclampsia on smooth muscle and endothelial cell function in arteries isolated from women

妊娠和先兆子痫对女性动脉平滑肌和内皮细胞功能的影响

• 批准号: nhmrc : 124470
• 负责人: Prof Helena Parkington
• 金额: $ 12.97万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-pregnancy-pre-isolated-women/82268
• 关键词: Effect; pregnancy; pre; eclampsia; smooth

During normal pregnancy the blood vessels of the mother become relaxed. This helps to meet the growing demands of the mother at this time and also ensures sufficient blood supply to the developing fetus. Blood vessels are lined by a single cell layer called the endothelium. The endothelium inactivates a variety of circulating agents which cause arteries to contract, and it also produces potent substances that directly relax the muscle cells in the blood vessel wall. Thus the endothelium plays an important role in the adaptation of the maternal blood vessels to pregnancy. Insufficient blood supply to the placenta somehow triggers myriad processes including endothelial dysfunction, enhanced clotting of the blood and contraction of the maternal blood vessels, which culminates in the serious disorder of pregnancy known as pre-eclampsia. This condition threatens the health of both mother and fetus, and in Australia, is responsible for 15% of direct maternal deaths and 10% of perinatal mortality. The focus of this project is to study the function of the endothelium and the muscle in the artery wall, and how the function of these entities is altered in the natural adaptation to pregnancy and in pre-eclampsia. The general aim of this study is two fold: (1) to determine how endothelial function adapts to pregnancy and how this is compromised in pre-eclampsia (2) to determine how factors released from the endothelium alone, or in combination with changes in inherent muscle function, alter the state of relaxation and contraction of muscle in the blood vessel wall, and the influence of pregnancy and of pre-eclampsia on these. This project will contribute to a greater understanding of the mechanisms that control the relaxation and contraction of blood vessels in normal pregnancy and those mechanisms that are impaired during pre-eclampsia and thus, may facilitate the development of treatments for this serious disorder.

在正常怀孕期间，母亲的血管会变得松弛。这有助于满足母亲此时不断增长的需求，并确保发育中的胎儿有足够的血液供应。血管由称为内皮的单细胞层排列。内皮细胞使多种导致动脉收缩的循环因子失活，并且还产生直接放松血管壁肌肉细胞的有效物质。因此，内皮细胞在母体血管对妊娠的适应中起着重要作用。胎盘供血不足会以某种方式引发多种过程，包括内皮功能障碍、血液凝固增强和母体血管收缩，最终导致严重的妊娠疾病，即先兆子痫。这种疾病威胁着母亲和胎儿的健康，在澳大利亚，这种疾病导致 15% 的孕产妇直接死亡和 10% 的围产期死亡率。该项目的重点是研究动脉壁内皮和肌肉的功能，以及这些实体的功能在自然适应妊娠和先兆子痫时如何改变。这项研究的总体目标有两个：（1）确定内皮功能如何适应妊娠，以及先兆子痫如何损害内皮功能；（2）确定内皮单独释放的因子，或与固有肌肉功能的变化相结合，如何改变血管壁肌肉的松弛和收缩状态，以及妊娠和先兆子痫对这些的影响。该项目将有助于更好地了解正常妊娠期间控制血管舒张和收缩的机制以及先兆子痫期间受损的机制，从而可能促进这种严重疾病的治疗方法的开发。