Role of endothelial vasodilator mechanisms in cardiovascular control during diabetes

内皮血管舒张机制在糖尿病期间心血管控制中的作用

• 批准号: nhmrc : 236872
• 负责人: Prof Helena Parkington
• 金额: $ 15.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-endothelial-vasodilator-control-diabetes/94962
• 关键词: Role; endothelial; vasodilator; mechanisms; cardiovascular

Cardiovascular diseases such as stroke and heart attack are the greatest killers in developed societies such as Australia. We now know that a number of metabolic disorders, and genetic and lifestyle factors, can increase the likelihood of individuals developing cardiovascular disease later in life, such as obesity, diabetes, and smoking. In many cases, individuals with these risk factors also have high blood pressure, which is a known cause of stroke and heart attack. This seems to be a particular problem in patients with diabetes, a condition that currently affects around 150 million people worldwide. Indeed, almost 70% of patients that develop diabetes in later life, also develop high blood pressure. The aim of the studies outlined in this application is to increase our understanding of the way diabetes affects blood pressure. High blood pressure often accompanies established diabetes, but we have recent evidence that suggests that a gas (nitric oxide) made by the cells that line blood vessels (endothelial cells) and in nerve cells, protects the cardiovascular system from hypertension during the onset of diabetes. Our experiments will show whether the 'protective' nitric oxide comes from nerves or the endothelial cells, and how it affects various blood pressure control mechanisms in diabetes. Our experiments will also show whether this protective action of nitric oxide is eventually lost as the organ damage that occurs in diabetes proceeds. This information should help in the design of new drug treatments and other therapies aimed at reducing the occurrence of high blood pressure, and hence cardiovascular disease, in diabetes.

在澳大利亚等发达社会，中风和心脏病等心血管疾病是最大的杀手。我们现在知道，一些代谢紊乱以及遗传和生活方式因素会增加个人在晚年患心血管疾病的可能性，如肥胖、糖尿病和吸烟。在许多情况下，具有这些危险因素的个人也有高血压，这是中风和心脏病发作的已知原因。这似乎是糖尿病患者的一个特别问题，目前全球约有1.5亿人患有糖尿病。事实上，近70%在晚年患上糖尿病的患者也会患上高血压。本申请中概述的研究的目的是增加我们对糖尿病影响血压的方式的理解。高血压通常伴随着糖尿病，但我们最近的证据表明，在糖尿病发作期间，血管(内皮细胞)和神经细胞中的细胞产生的气体(一氧化氮)可以保护心血管系统免受高血压的影响。我们的实验将展示“保护性”一氧化氮是来自神经还是内皮细胞，以及它是如何影响糖尿病的各种血压控制机制的。我们的实验还将表明，随着糖尿病器官损害的进行，一氧化氮的这种保护作用是否最终会消失。这些信息应该有助于设计新药疗法和其他疗法，旨在减少糖尿病中高血压的发生，从而减少心血管疾病。