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3Dimensional Reactions: A new Approach to Chemical Catalysis using 3D Printed Devices

3D 反应：使用 3D 打印设备进行化学催化的新方法

基本信息

批准号：
1810639
负责人：
金额：
--
依托单位：
University College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1810639
关键词：
3Dimensional Reactions new Approach Chemical

项目摘要

Chemical reactions to produce active pharmaceutical ingredients (APIs) are carried out on scales ranging from milligram amounts in drug discovery laboratories through to large kiloton reactors in process laboratories. In both cases, reactions are mixed via internal magnetic follower or via larger externally controlled reactor paddles. In a new approach, the Hilton group has developed novel patented 3D Printed devices that can be used to efficiently mix reactions and which contain impregnated catalysts to both mix and catalyse chemical reactions at the same time, making the entire process simpler to carry out. The devices are produced using 3D printing in the Hilton laboratory and the catalyst is impregnated in the device at the point of printing.These devices are used to speed up the drug discovery process, guiding synthesis from discovery through to process laboratories. This new and exciting project will involve exploring the scope of these devices to catalyse a range of reactions andthe development of new devices and applications. The project will explore the scope of catalysts that can be incorporated and their potential to catalyse a range of chemical reactions.Main Methods and Techniques to be employed:The project focuses on synthetic chemistry alligned with 3D printing in a novel and fast growing area. The project will involve chemical synthesis and the design and development of novel 3D printed devices. Techniques used will include chemical synthesis, catalysis, 3D Design, 3D printing and automatic purification. The student employed in the project will also be encouraged to publish as widely as possible in this novel area.

生产活性药物成分(原料药)的化学反应的规模从药物发现实验室的毫克量到过程实验室的大型千吨反应堆不等。在这两种情况下，反应通过内部磁跟随器或通过更大的外部控制的反应堆桨混合。在一种新的方法中，希尔顿集团开发了新型获得专利的3D打印设备，这种设备可以用于有效地混合反应，并且包含浸渍的催化剂，可以同时混合和催化化学反应，使整个过程更容易执行。这些装置是在希尔顿实验室使用3D打印技术生产的，在打印点将催化剂浸入装置中。这些装置用于加快药物发现过程，指导从发现到过程实验室的合成。这个新的和令人兴奋的项目将涉及探索这些设备的范围，以催化一系列反应和新设备和应用的开发。该项目将探索可整合的催化剂的范围及其催化一系列化学反应的潜力。将采用的主要方法和技术：该项目专注于合成化学，并在一个新的和快速增长的领域与3D打印相结合。该项目将涉及化学合成和新型3D打印设备的设计和开发。使用的技术将包括化学合成、催化、3D设计、3D打印和自动净化。受雇于该项目的学生也将被鼓励在这一小说领域尽可能广泛地发表文章。