XAS STRUCTURAL CHARACTERIZATION OF NO ADDUCTS OF HEMES

一氧化氮(NO)被发现具有越来越多的 生物学作用，包括作为神经递质。在各种各样的 这些功能，已知NO与血红素蛋白结合，但NO 关于这种结构的性质，可以获得详细的结构信息 有约束力的。本项目旨在使用XAS数据来了解 亚铁血红素蛋白加合物的几何和电子结构。 这些结构信息也将被用来获得更好的 了解结合NO是如何激活释放 非血红素基团来自于血红素蛋白。

Nitric oxide (NO) has been found to have an increasing number of biological roles including being a neurotransmitter. In a variety of these functions, it is known that NO is bound to heme proteins, but no detailed structural information is available on the nature of such binding. This project is aimed at using XAS data to understand the geometric and electronic structures of NO adducts of heme proteins. This structural information will also be used to gain a better understanding of how binding of NO activates the release of the NO-heme group from the heme protein.