Kinetic Simulations of Minimal Living Systems
Kinetic Simulations of Minimal Living Systems
批准号:
6367767
负责人:
PAUL A. LINDAHL
金额:
$10.91万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-08-01 至 2003-07-31
中文摘要
描述(由申请人提供):鉴于信息爆炸
英文摘要
DESCRIPTION (provided by the applicant): Given the information explosion
accruing among the biological sciences, it is likely that, within a decade, the
composition of simple living systems and the functions of every gene/protein
contained therein will be understood. At that point, it may be possible, for
the first time, to understand the property of life on a molecular level.
Anticipating this, the goal of this proposal is to develop a methodology that
uses this information to simulate the kinetics of minimal living systems at the
molecular level (part I) and to apply this methodology to simulate the simplest
organism, Mycoplasma genitalium (part II). The methodology will be developed
using Mechanical Cells, simple hypothetical self-replicating systems with
properties analogous to those of real cells. The methodology involves
decomposing such systems into hierarchically organized structures and
functions. These will be reorganized into mechanistic modules, collections of
elementary chemical reactions (explicating the mechanism of the module) and the
associated molecular components. Complete sets of modules must be
autocatalytic, a required property of living systems. The ordinary differential
equations corresponding to this reaction set will be generated and solved
numerically. This will require simplifying and/or subdividing the system,
solving the simpler system than linking. The resulting set of rate constants
and copy numbers will be used in conjunction with a stochastic computer
simulator to generate kinetic plots of each molecular component. The output of
the simulations will be animated using 3D visualization software. Simulation
and animations will be critically compared to the properties of real cells.
Mechanism will be modified, corrected, and embellished as deficiencies are
noted and more experimental data become available.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Iron Trafficking and Regulation in Biological Systems
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批准号:9910417
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项目类别:
-
资助金额:$34.7万
-
财政年份:2018
-
负责人:PAUL A. LINDAHL
-
依托单位:
Iron Trafficking and Regulation in Biological Systems
-
批准号:10393033
-
项目类别:
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资助金额:$34.66万
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财政年份:2018
-
负责人:PAUL A. LINDAHL
-
依托单位:
Iron in Mitochondrial Physiology and Disease
-
批准号:8119021
-
项目类别:
-
资助金额:$29.18万
-
财政年份:2009
-
负责人:PAUL A. LINDAHL
-
依托单位:
Iron in Mitochondrial Physiology and Disease
-
批准号:8302428
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项目类别:
-
资助金额:$29.15万
-
财政年份:2009
-
负责人:PAUL A. LINDAHL
-
依托单位:
Iron in Mitochondrial Physiology and Disease
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批准号:7896648
-
项目类别:
-
资助金额:$28.37万
-
财政年份:2009
-
负责人:PAUL A. LINDAHL
-
依托单位:
Iron in Mitochondrial Physiology and Disease
-
批准号:8632557
-
项目类别:
-
资助金额:$29.9万
-
财政年份:2009
-
负责人:PAUL A. LINDAHL
-
依托单位:
Training at the Chemistry: Biology Interface
-
批准号:7883892
-
项目类别:
-
资助金额:$12.81万
-
财政年份:2009
-
负责人:PAUL A. LINDAHL
-
依托单位:
Kinetic Simulations of Minimal Living Systems
-
批准号:6526127
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项目类别:
-
资助金额:$10.91万
-
财政年份:2001
-
负责人:PAUL A. LINDAHL
-
依托单位:
Training at the Chemistry: Biology Interface
-
批准号:7882598
-
项目类别:
-
资助金额:$4.94万
-
财政年份:1994
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负责人:PAUL A. LINDAHL
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依托单位:
Synthetic Molecules in Biological Systems
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批准号:7097252
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项目类别:
-
资助金额:$8.43万
-
财政年份:1994
-
负责人:PAUL A. LINDAHL
-
依托单位:
Training at the Chemistry: Biology Interface
-
批准号:7631566
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项目类别:
-
资助金额:$6.4万
-
财政年份:1994
-
负责人:PAUL A. LINDAHL
-
依托单位:
BIOINORGANIC CHEMISTRY OF CARBON MONOXIDE DEHYDROGENASE
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批准号:2183919
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项目类别:
-
资助金额:$16.19万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
BIOINORGANIC CHEMISTRY--CARBON MONOXIDE DEHYDROGENASE
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批准号:6519460
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项目类别:
-
资助金额:$16.93万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
Bioinorganic Chemistry of Carbon Monoxide Dehydrogenase
-
批准号:6733568
-
项目类别:
-
资助金额:$25.46万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
Bioinorganic Chemistry of Carbon Monoxide Dehydrogenase
-
批准号:7687538
-
项目类别:
-
资助金额:$30.51万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
BIOINORGANIC CHEMISTRY OF CARBON MONOXIDE DEHYDROGENASE
-
批准号:2392153
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项目类别:
-
资助金额:$13.57万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
BIOINORGANIC CHEMISTRY OF CARBON MONOXIDE DEHYDROGENASE
-
批准号:3305872
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项目类别:
-
资助金额:$14.46万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
BIOINORGANIC CHEMISTRY--CARBON MONOXIDE DEHYDROGENASE
-
批准号:6179369
-
项目类别:
-
资助金额:$16.23万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
Bioinorganic Chemistry of Carbon Monoxide Dehydrogenase
-
批准号:7882663
-
项目类别:
-
资助金额:$28.87万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
Bioinorganic Chemistry of Carbon Monoxide Dehydrogenase
-
批准号:8104275
-
项目类别:
-
资助金额:$28.57万
-
财政年份:1993
-
负责人:PAUL A. LINDAHL
-
依托单位:
海外基金