Training at the Chemistry: Biology Interface

化学：生物界面培训

• 批准号: 7882598
• 负责人: PAUL A. LINDAHL
• 金额: $ 4.94万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7882598
• 关键词: Biology; Chemistry; Training

DESCRIPTION (provided by applicant): Multidisciplinary research at the Chemistry: Biology interface has expanded so rapidly in the past few decades that such cross-training is now crucial for the development of the next generation of chemists and biologists. The objectives of the proposed training program at Texas A&M University are to train predoctotal graduate students in the Chemistry, Biochemistry and Biophysics, and Biology departments in research at the Chemistry: Biology Interface (CBI). Since its inception in 1994, this NIH-sponsored program has played a major role in the successful training of our graduate students in the molecular life sciences. The program currently involves 27 faculty members, with highly diverse research interests including : a) mechanistic enzymology (Raushel), b) macromolecular interactions (Hu, Reinhart, Schultz); c) synthesis (Burgess,Connell, Darensbourg, Romo, Yang); d) bioanalysis (Cremer, Russell, Vigh); e) metabolism (Begley, Lindahl,Watanabe); f) structure/function relationships (Barondeau, Hilty, Sacchettini); g) computational reaction mechanisms (Gao, Singleton); h) chronobiology (Golden and Bell-Pederson); i) behavioral biology (Garcia)and j) chemical biology (Pellois, Liu, Ryan, Young). Such diversity is a major strength of our CBI program, as it makes it attractive to a wider range of students and affords for greater cross-training at the Chemistry: Biology interface. Students in the CBI program choose one of these trainers as their primary research advisor, and enroll in a core group of required courses in which training in quantitative biology is stressed. CBI students enroll in a weekly journal club, in which research topics from this area are discussed, emphasizing the connection to human health, physiology and disease. Students also enroll in class on the Ethical Conduct of Research. The CBI program sponsors an annual symposium in which existing trainees present their research results and new trainees are introduced into the program. Well known external speakers are also invited as part of the training program. A former CBI student is invited to help current CBI students develop their careers. Towards the end of this 2-year program, students apply to attend a summer workshop course at an external location in which classroom and laboratory instruction are combined in an intense scientific setting. The CBI program also supports CBI students to attend a scientific conference annually.

描述（由申请人提供）：在过去的几十年里，化学和生物学领域的多学科研究迅速发展，这种交叉培训现在对下一代化学家和生物学家的发展至关重要。德克萨斯农工大学拟议的培训计划的目标是培养化学、生物化学和生物物理学以及生物系的博士前研究生在化学：生物界面（CBI）进行研究。自1994年成立以来，这个由美国国立卫生研究院赞助的项目在成功培养分子生命科学研究生方面发挥了重要作用。该项目目前有27名教职员工，他们的研究兴趣非常多样化，包括：a)机械酶学（Raushel）， b)大分子相互作用（Hu, Reinhart, Schultz）；c)合成（Burgess,Connell, Darensbourg, Romo, Yang）；d)生物分析（Cremer, Russell, Vigh）；e)代谢（Begley, Lindahl,Watanabe）；f)结构/功能关系（Barondeau、Hilty、Sacchettini）；g)计算反应机理（Gao, Singleton）；h)时间生物学（Golden and Bell-Pederson）；i)行为生物学（Garcia）和j)化学生物学（Pellois, Liu, Ryan, Young）。这种多样性是我们CBI项目的主要优势，因为它使其对更广泛的学生具有吸引力，并在化学和生物界面上提供了更多的交叉训练。CBI项目的学生选择其中一名培训师作为他们的主要研究顾问，并参加一组核心必修课程，其中强调定量生物学的培训。CBI的学生参加一个周刊俱乐部，在那里讨论该领域的研究课题，强调与人类健康、生理学和疾病的联系。学生们还参加了关于研究伦理行为的课程。CBI项目每年举办一次研讨会，现有的学员在会上展示他们的研究成果，并向新学员介绍他们的研究成果。作为培训计划的一部分，还邀请了知名的外部演讲者。一位前CBI学生被邀请帮助现在的CBI学生发展他们的职业生涯。在这个为期两年的课程即将结束时，学生们申请参加一个外部地点的夏季工作坊课程，在这个课程中，课堂和实验室教学在一个强烈的科学环境中结合起来。CBI项目还支持CBI学生每年参加一次科学会议。

项目成果

Perturbations to the active site of phosphotriesterase.

• DOI: 10.1021/bi962099l
• 发表时间: 1997-02
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: J. Kuo;M. Chae;F. Raushel

Biophysical characterization of iron in mitochondria isolated from respiring and fermenting yeast.

• DOI: 10.1021/bi100558z
• 发表时间: 2010-07-06
• 期刊: BIOCHEMISTRY
• 影响因子: 2.9
• 作者: Morales, Jessica Garber;Holmes-Hampton, Gregory P.;Miao, Ren;Guo, Yisong;Muenck, Eckard;Lindahl, Paul A.
• 通讯作者: Lindahl, Paul A.

De novo design and spectroscopic characterization of a dinucleating copper-binding pentadecapeptide.

双核铜结合十五肽的从头设计和光谱表征。

• DOI: 10.1021/ic051577q
• 发表时间: 2006
• 期刊: Inorganic chemistry.
• 作者: Rockcliffe,DavidA;Cammers,Arthur;Murali,Ayaluru;Russell,WilliamK;DeRose,VictoriaJ
• 通讯作者: DeRose,VictoriaJ

Effects of substitution at serine 40 of tyrosine hydroxylase on catecholamine binding.

酪氨酸羟化酶丝氨酸 40 处的取代对儿茶酚胺结合的影响。

• DOI: 10.1021/bi010546d
• 发表时间: 2001
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: McCulloch,RI;Daubner,SC;Fitzpatrick,PF
• 通讯作者: Fitzpatrick,PF

NiN(2)S(2) complexes as metallodithiolate ligands to Rh(I), Rh(II) and Rh(III).

NiN(2)S(2) 作为金属二硫醇盐配体与 Rh(I)、Rh(II) 和 Rh(III) 形成络合物。

• DOI: 10.1039/b605768c
• 发表时间: 2006
• 期刊: Dalton transactions (Cambridge, England : 2003)
• 作者: Jeffery,StephenP;Green,KaylaN;Rampersad,MarilynV;Reibenspies,JosephH;Darensbourg,MarcettaY
• 通讯作者: Darensbourg,MarcettaY