PREDOCTORAL TRAINING PROGRAM IN MOLECULAR THERAPEUTICS

描述：(由申请人提供)这份新的申请请求支持凯斯西储大学(CWRU)分子治疗学博士前培训计划。申请申请要求在资助的第一年资助三名博士前学生，资助期限总计为五年。这一培训计划的全球目标是为博士前学生提供必要的知识基础和技能，以便在药理学领域开始独立的研究和教学生涯。该计划的近期目标是在整个培训过程中促进对学生的培训、评估和咨询，为了满足他们的长期职业目标，该计划本身包括现代药理学基本原理的广泛教学培训，并将其整合到跨学科、多方面的研究培训体验中。教学和研究部分都强调分子、细胞、生化和遗传学方法，以了解药物作用的机制，并将治疗剂的使用作为探索生理和病理生理过程的重要工具。教学部分包括强调药理学基本原理的必修核心课程，以及以核心原理为基础的高级选修课。研究项目集中在三个主要的重点领域，1)受体和信号，2)激素反应性恶性肿瘤，3)药物基因组学。在许多关键领域提供持续培训，包括指导、口头/书面交流技能和对科学文献的批判性分析，使用各种学习形式，包括期刊俱乐部、研讨会、晚间座谈、讲习班和务虚会。这一跨学科培训计划由33名教员培训人员组成，他们来自重庆大学医学院附属的11个不同的基础和临床部门。这个项目中的培训师是一个高度互动、协作的团队，他们在博士后和博士后层面的培训方面都有相当的经验。他们是各自领域的领导者，已经获得了超过1300万美元的国家资金，用于支持该项目的博士前研究。总而言之，这个项目将为博士前学生提供高级培训、教育和技术经验，这些经验是这些学生成为未来药理学教育和研究的领导者所必需的。

DESCRIPTION: (provided by applicant) This new application requests support for the Predoctoral Training Program in Molecular Therapeutics at Case Western Reserve University (CWRU). The application requests support for three predoctoral students in the first year of support with a total funding period of five years. The global objective of this training program is to provide predoctoral students with the necessary knowledge base and skills to begin independent investigative and teaching careers in the pharmacological sciences. The immediate goals of the program are to foster the training, evaluation and counseling of students throughout their training and in meeting their long-term career objectives, The program itself is composed of broad-based, didactic training in fundamental principles of modem pharmacology that is integrated into an interdisciplinary, multi-faceted research training experience. Both the didactic and research components emphasize molecular, cellular, biochemical, and genetic approaches to understand mechanisms of drug action and the use of therapeutic agents as important tools to probe physiological and pathophysiological processes. The didactic component consists of required core courses that emphasize fundamental principles in pharmacology as wen as advanced electives that build on core principles. Research projects center on three major focal areas, 1) receptors and signaling, 2) hormone responsive malignancies, and 3) pharmacogenomics. Continuing training is offered in a number of key areas including mentoring, verbal/written communication skills, and critical analysis of the scientific literature, using a variety of learning formats including journal clubs, seminars, evening colloquia, workshops, and retreats. This interdisciplinary training program consists of 33 faculty trainers from 11 different basic and clinical departments affiliated with the School of Medicine at CWRU. The trainers in this program are a highly interactive, collaborative group that have considerable experience in training at both the predoctoral and postdoctoral levels. They are leaders in their respective fields and have generated over $13 million dollars in national funding to support predoctoral research in this program. In summary, this program will provide predoctoral students with advanced training, education, and the technical experience that is necessary for these students to become the future leaders in education and research in the pharmacological sciences.