Predoctoral Training Program in Human Genetics

人类遗传学博士前培训项目

• 批准号: 10555383
• 负责人: Kimberly F Doheny
• 金额: $ 58.36万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555383
• 关键词: Human Genetics; Training Programs; pre-doctoral

PROJECT SUMMARY The Johns Hopkins Predoctoral Training Program in Human Genetics (HG) has long been a nationally preeminent training environment for human genetic research. It has grown steadily since its inception (1980) in parallel to the explosive growth of genetics and genomics, and their application to medicine. Although supported by preceptor faculty across 20 diverse departments, the HG has its administrative and philosophical home in the McKusick-Nathans Department of Genetic Medicine (DGM). Eighty faculty mentors engage in training our current cohort of sixty-one students. The preceptors’ research includes human and model organism genetics and genomics, study of genes and variants underlying human monogenic disorders and complex traits, quantitative genetics, gene therapy, oncogenetics, stem cells, technology development, big data and machine learning. An average of 12 students graduate each year and obtain their PhD in 5.3 years (average). The objectives of the HG program are: (1) to provide a biomedical curriculum with breadth and depth; (2) to ensure an understanding of the fundamental roles of genetic variation in human biology, diversity, and disease; (3) to provide robust training in rigorous, reproducible, responsible, and ethical research; (4) to equip our trainees with relevant professional skills and the opportunity to explore career options; and (5) to recruit and foster a diverse and inclusive training environment for all. In the first year, we introduce students to the evolving concepts of the gene, molecular biology, genomics, cell structure and dynamics, pathways and regulation, extending deeper with advanced topics in human genetics. We introduce a new computational bootcamp to provide fundamental computational and statistical skills, a theme that is iterated throughout their courses. In their second year we have developed two highly innovative courses: Systems, Genes and Mechanisms in Disease and Genomic Technologies Applications and Considerations. The courses integrate didactic presentation with student-led seminars, team-based problem solving and discussion, placing their genetic training in a human biological and pathological context and equipping them for the design and implementation of contemporary genomic experimental strategies. We provide training in rigorous and ethical experimental design and implementation, and career planning and professional development through workshops, internship opportunities and required courses. Our preceptors receive mentoring training; are appropriately mentored; and they are accountable. The overall goal of our HG program is to educate the next generation of leaders in human genetics. We seek to train independent scientists who are passionately curious about the role that genetic variation plays in the human condition. This education prepares our students to answer important basic science questions and to translate this information into bio-medical advances. The success of our graduates, in pursuing academic careers, roles in government, private sector research, or using genetics in law and public policy supports this. We request 14 training grant slots to support training grant eligible students during their first year in the program.

项目摘要 约翰霍普金斯博士前培训计划在人类遗传学（HG）长期以来一直是一个全国性的 人类基因研究的最佳训练环境。自1980年成立以来，它一直在稳步增长。 与遗传学和基因组学的爆炸性增长及其在医学上的应用平行。虽然支持 由导师教师在20个不同的部门，HG有其行政和哲学家在 McKusick-Nathans遗传医学系（DGM）。80名教师导师参与培训我们目前的 61名学生。导师的研究包括人类和模式生物遗传学， 基因组学，研究人类单基因疾病和复杂性状的基因和变异，定量 遗传学、基因治疗、肿瘤遗传学、干细胞、技术开发、大数据和机器学习。 平均每年有12名学生毕业，并在5.3年内获得博士学位（平均）。目标 HG计划的主要目标是：（1）提供具有广度和深度的生物医学课程;（2）确保 了解遗传变异在人类生物学、多样性和疾病中的基本作用;（3） 提供严格的，可重复的，负责任的和道德的研究强有力的培训;（4）使我们的学员具备 （5）招聘和培养多元化的专业人才， 和包容性的培训环境。在第一年，我们向学生介绍不断发展的概念， 基因，分子生物学，基因组学，细胞结构和动力学，途径和调节， 人类遗传学的前沿课题。我们引入了一个新的计算训练营，以提供基本的 计算和统计技能，这是一个主题，在他们的课程迭代。第二年，我们 我开发了两个高度创新的课程：系统，基因和疾病机制和基因组 技术应用和注意事项。这些课程将教学演示与学生主导的 研讨会，以团队为基础的问题解决和讨论，把他们的遗传训练在一个人类生物学和 病理背景和装备他们的设计和实施当代基因组 实验策略。我们提供严格和道德的实验设计和实施培训， 通过讲习班、实习机会和必要的培训， 课程我们的导师接受指导培训;得到适当的指导;他们是负责任的。 我们的HG计划的总体目标是教育人类遗传学的下一代领导者。我们 寻求培养独立的科学家，他们对遗传变异在人类进化中所起的作用充满热情。 人类的状况。这种教育使我们的学生能够回答重要的基础科学问题， 将这些信息转化为生物医学的进步。我们的毕业生的成功，在追求学术 职业，在政府，私营部门研究中的作用，或在法律和公共政策中使用遗传学支持这一点。 我们申请14个培训补助金名额，以支持符合培训补助金条件的学生在他们的第一年在该计划。