PREDOCTORAL TRAINING PROGRAM IN MOLECULAR THERAPEUTICS

产品说明：（由申请人提供）这个新的应用程序请求支持在凯斯西储大学（CWRU）的分子治疗学博士前培训计划。申请要求在第一年支持三名博士前学生，总资助期为五年。该培训计划的全球目标是为博士前学生提供必要的知识基础和技能，以开始独立的药理学研究和教学生涯。该计划的直接目标是在整个培训过程中促进学生的培训，评估和咨询，并满足他们的长期职业目标，该计划本身由现代药理学基本原理的基础广泛的教学培训组成，该培训整合到跨学科，多方面的研究培训经验中。教学和研究部分都强调分子，细胞，生物化学和遗传学方法来理解药物作用机制和使用治疗剂作为探测生理和病理生理过程的重要工具。教学部分包括必修的核心课程，强调药理学的基本原则，以及建立在核心原则基础上的高级选修课。研究项目集中在三个主要重点领域，1）受体和信号传导，2）激素反应性恶性肿瘤，和3）药物基因组学。继续培训提供了一些关键领域，包括指导，口头/书面沟通技巧，和科学文献的批判性分析，使用各种学习形式，包括期刊俱乐部，研讨会，晚上座谈会，研讨会和务虚会。该跨学科培训计划由来自CWRU医学院附属的11个不同基础和临床部门的33名教师培训师组成。该计划的培训师是一个高度互动，协作的团队，在博士前和博士后水平的培训方面都有相当丰富的经验。他们是各自领域的领导者，并已产生超过1300万美元的国家资金，以支持该计划的博士前研究。总之，该计划将为博士前学生提供先进的培训，教育和技术经验，这些学生成为药理学科学教育和研究的未来领导者。

DESCRIPTION: (provided by applicant) This new application requests support for the Predoctoral Training Program in Molecular Therapeutics at Case Western Reserve University (CWRU). The application requests support for three predoctoral students in the first year of support with a total funding period of five years. The global objective of this training program is to provide predoctoral students with the necessary knowledge base and skills to begin independent investigative and teaching careers in the pharmacological sciences. The immediate goals of the program are to foster the training, evaluation and counseling of students throughout their training and in meeting their long-term career objectives, The program itself is composed of broad-based, didactic training in fundamental principles of modem pharmacology that is integrated into an interdisciplinary, multi-faceted research training experience. Both the didactic and research components emphasize molecular, cellular, biochemical, and genetic approaches to understand mechanisms of drug action and the use of therapeutic agents as important tools to probe physiological and pathophysiological processes. The didactic component consists of required core courses that emphasize fundamental principles in pharmacology as wen as advanced electives that build on core principles. Research projects center on three major focal areas, 1) receptors and signaling, 2) hormone responsive malignancies, and 3) pharmacogenomics. Continuing training is offered in a number of key areas including mentoring, verbal/written communication skills, and critical analysis of the scientific literature, using a variety of learning formats including journal clubs, seminars, evening colloquia, workshops, and retreats. This interdisciplinary training program consists of 33 faculty trainers from 11 different basic and clinical departments affiliated with the School of Medicine at CWRU. The trainers in this program are a highly interactive, collaborative group that have considerable experience in training at both the predoctoral and postdoctoral levels. They are leaders in their respective fields and have generated over $13 million dollars in national funding to support predoctoral research in this program. In summary, this program will provide predoctoral students with advanced training, education, and the technical experience that is necessary for these students to become the future leaders in education and research in the pharmacological sciences.