CRYSTALLOGRAPHIC STUDY OF E COLI SINGLE STRANDED DNA BINDING PROTEIN (SSB) IN

单链DNA结合（SSB）蛋白是一类 在DNA中起重要作用的非特异性DNA结合蛋白 新陈代谢. 所有生物，包括大多数噬菌体和病毒， 编码自己的SSB蛋白，所有这些蛋白都优先结合， 对单链DNA（ssDNA）具有高亲和力。 这些蛋白质 也通常以一定程度的协同性结合ssDNA， 当与ssDNA结合时， 并被推定至少部分地通过约束和 在复制、重组过程中瞬时形成的饱和ssDNA 和修复。

Single-stranded DNA binding (SSB) proteins are a class of nonspecific DNA binding proteins that play essential roles in DNA metabolism. All organisms, including most bacteriophage and viruses, encode their own SSB proteins, all of which bind preferentially and with high affinity to single-stranded DNA (ssDNA). These proteins also generally bind ssDNA with some degree of cooperativity resulting in the tendency to form long clusters of protein when bound to ssDNA and are presumed to function, at least partly, by binding to and saturating ssDNA formed transiently during replication, recombination and repair.