CRYSTALLOGRAPHIC ANALYSIS OF SESQUITERPENE CYCLASES

倍半萜环化酶的晶体分析

• 批准号: 6437586
• 负责人: COURTNEY STARKS
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6437586
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; plants; proteins; radiography; structural biology

Plant derived cyclic terpenoids including monoterpenoids derived from geranyl diphosphate, sesquiterpenoids derived from farnesyl diphosphate and diterpenoids derived from geranylgeranyl diphosphate, comprise a significant class of secondary metabolites that mediate a plant's interaction with its environment. From a health related perspective, these compounds also represent an important class of potential antibiotic, antifungal and anti tumor agents. The objective of our research is to understand as completely as possible the structural, functional and chemical features governing two distinct stereochemically controlled cyclizations of farnesyl diphosphate (FPP) catalyzed by two highly homologous plant sesquiterpene cyclases that result in two unique bicyclic products.

植物衍生的环状萜类化合物，包括衍生的单萜类化合物 来自二磷酸香叶基、法呢基衍生的倍半萜类化合物 衍生自香叶基香叶基二磷酸的二磷酸盐和二萜类化合物， 包含一类重要的次生代谢物，介导 植物与其环境的相互作用。 来自健康相关 从角度来看，这些化合物也代表了一类重要的 潜在的抗生素、抗真菌和抗肿瘤药物。 目标 我们研究的目的是尽可能全面地了解 控制两种不同的结构、功能和化学特征 法呢基二磷酸 (FPP) 的立体化学控制环化 由两种高度同源的植物倍半萜环化酶催化 产生两种独特的双环产物。