CRYSTALLOGRAPHIC ANALYSIS OF SESQUITERPENE CYCLASES

植物来源的环状萜类化合物，包括单萜类化合物 来源于香叶基二磷酸，来源于法尼基的倍半萜类化合物 香叶基香叶基二磷酸衍生的二磷酸和二萜类化合物， 包含一类重要的次生代谢物，这些次生代谢物介导 植物与环境的相互作用。来自一家健康相关的 从角度来看，这些化合物也代表了一类重要的 潜在的抗生素、抗真菌和抗肿瘤药物。目标是 我们研究的重点是尽可能全面地了解 结构、功能和化学特征支配着两个不同的 法尼基二磷酸(FPP)的立体化学控制环化反应 由两个高度同源的植物倍半萜环酶催化 产生了两个独特的双环产品。

Plant derived cyclic terpenoids including monoterpenoids derived from geranyl diphosphate, sesquiterpenoids derived from farnesyl diphosphate and diterpenoids derived from geranylgeranyl diphosphate, comprise a significant class of secondary metabolites that mediate a plant's interaction with its environment. From a health related perspective, these compounds also represent an important class of potential antibiotic, antifungal and anti tumor agents. The objective of our research is to understand as completely as possible the structural, functional and chemical features governing two distinct stereochemically controlled cyclizations of farnesyl diphosphate (FPP) catalyzed by two highly homologous plant sesquiterpene cyclases that result in two unique bicyclic products.