HIGH RESOLUTION DATA ON HUMAN CATALASE

过氧化氢酶是一种关键的抗氧化酶 构成了对抗超氧化物和氢的主要防御系统 过氧化氢通过将过氧化氢转化为水和氧气。牛过氧化氢酶 与NADPH络合的结构在十年前就被解析到2.5E。 从那时起，结合的NADPH的作用就鲜为人知， 人类酶的结构，尽管它在 细胞氧化还原电位在细胞凋亡中的调节作用 病原体、DNA损伤和衰老一直被忽视。鉴于中央 对于过氧化氢酶在人类中的作用，我们希望研究其结构基础 人过氧化氢酶通过结晶学结合信使核糖核酸。

Catalase is one of the critical antioxident enzymes that constitutes a major defense system against superoxide and hydrogen peroxide by converting H2O2 to H2O and O2. The bovine catalase structure complexed with NADPH was solved to 2.5 E a decade ago. Since that time, the role of the bound NADPH is poorly understood and the structure of the human enzyme, despite its critical role in regulation of the cellular redox potential in apoptosis, response to pathogens, DNA damage and aging, has been ignored. Given the central role of catalase in humans, we wish to examine the structural basis of mRNA binding by human catalase through crystallography.