HUMAN IMP DEHYDROGENASE

人IMP脱氢酶（IMPDH）催化NAD依赖性的 将IMP氧化为XMP，使其成为合成 鸟嘌呤核苷酸。 酶的两种异构体存在， 两种形式共有约84%的序列同一性。 有证据 II型IMPDH的抑制剂是有效的抗增殖剂， 药物，并可用于控制某些形式的癌症。 它有 还显示，如果IMPDH具有免疫抑制作用， 活动 未来努力了解和利用治疗 抑制IMPDH活性的益处是 这对获得这种酶的结构有很大帮助。

Human IMP dehydrogenase (IMPDH) catalyzes the NAD-dependent oxidation of IMP to XMP, making it a key component in the synthesis of guanine nucleotides. Two isoforms of the enzyme exit and these two forms share approximately 84% sequence identity. There is evidence that inhibitors of type II IMPDH are effective antiproliferative agents, and may be useful in controlling some forms on cancer. It has also been shown that inhibitors if IMPDH have immunosuppressive activity. Future efforts to understand and utilize the therapeutic benefits resulting from the inhibition of IMPDH activity would be greatly aided by obtaining the structure of this enzyme.