人IMP脱氢酶-猫眼课题宝

人IMP脱氢酶

批准号：

6658599

负责人：

JOHN R SOMOZA

金额：

$14.32万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-03-01 至 2003-02-28

来源：

https://reporter.nih.gov/project-details/6658599

关键词：

bioimaging /biomedical imaging biomaterials biomedical resource genome radiography structural biology

项目摘要

项目成果

JOHN R SOMOZA的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Human IMP dehydrogenase (IMPDH) catalyzes the NAD-dependent oxidation of IMP to XMP, making it a key component in the synthesis of guanine nucleotides. Two isoforms of the enzyme exit and these two forms share approximately 84% sequence identity. There is evidence that inhibitors of type II IMPDH are effective antiproliferative agents, and may be useful in controlling some forms on cancer. It has also been shown that inhibitors if IMPDH have immunosuppressive activity. Future efforts to understand and utilize the therapeutic benefits resulting from the inhibition of IMPDH activity would be greatly aided by obtaining the structure of this enzyme.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文